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首页> 外文会议>World congress on medical physics and biomedical engineering;International congress of the IUPESM >Non-linear resistance associated to complex geometry at high flow rates in vascular access for hemodialysis
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Non-linear resistance associated to complex geometry at high flow rates in vascular access for hemodialysis

机译：血液透析中高流速下与复杂几何形状相关的非线性阻力

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Successful maturation and long-term function of a vascular access for hemodialysis relies on the creation and maintenance a low-resistance route between the arterial and the venous system. In this work, we demonstrate how vascular segments characterized by complex geometry can be associated with non-linear resistance behavior at the sustained flow rates required for hemodialysis treatment. Using an image-based computational hemodynamics approach, we determine the relationship between flow rate and pressure drop in two kink geometries obtained from CE-MRA of a native arterio-venous fistula and a synthetic loop graft, respectively. Experimental validation of the predicted pressure drops across the loop graft kink is shows excellent agreement with the computational findings. The increase in pressure drop obtained at the high flow rates required for hemodialysis may lead to the inability for the vascular access to mature or maintain a sufficient flow rate for renal replacement therapy. For this reason, a patient-specific analysis of the relationships between geometry and resistance in realistic vascular access configurations may help at ameliorating the outcomes of vascular access creation and function.
机译：血管通路用于血液透析的成功成熟和长期功能取决于在动脉和静脉系统之间建立和维持低阻力的途径。在这项工作中，我们演示了在复杂的血液透析治疗所需的持续流速下，具有复杂几何特征的血管节段如何与非线性阻力行为相关联。使用基于图像的计算血液动力学方法，我们确定了分别从天然动静脉瘘的CE-MRA和合成环移植物获得的两种扭结几何形状中流速与压降之间的关系。跨环移植物纽结的预测压降的实验验证与计算结果非常吻合。在血液透析所需的高流速下获得的压降增加可能导致血管无法成熟或无法维持足够的流速进行肾脏替代治疗。由于这个原因，对实际血管通路构型中几何形状和阻力之间关系的患者特定分析可能有助于改善血管通路产生和功能的结果。

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