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首页> 外文会议>Conference on physiology and function from multidimensional images >Functional magnetic resonance imaging of the rat cerebellum during electrical stimulation of the fore- and hindpaw at 7 T
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Functional magnetic resonance imaging of the rat cerebellum during electrical stimulation of the fore- and hindpaw at 7 T

机译：在7℃下电刺激刺激期间大鼠小脑的功能磁共振成像

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Blood oxygenation level dependent contrast (BOLD) functional MRI responses at 7T were observed in the cerebellum of alpha- chloralose anesthetized rats in response to innocuous electrical stimulation of a forepaw or hindpaw. The responses were imaged in both coronal and sagittal slices which allowed for a clear delineation and localization of the observed activations. We demonstrate the validity of our fMRI protocol by imaging the responses in somatosensory cortex to the same stimuli and by showing a high level of reproducibility of the cerebellar responses. Widespread bilateral activations were found with mainly a patchy and medio-lateral band organization, more pronounced ipsilaterally. There was no overlap between the cerebellar activations caused by forepaw or hindpaw stimulation. Most remarkable was the overall horizontal organization of these responses: for both stimulation paradigms the patches and bands of activation were roughly positioned in either a cranial or caudal plane running antero-posteriorly through the whole cerebellum. This is the first fMRI study in the cerebellum of the rat. We relate our findings to the known projection patterns found with other techniques and to human fMRI studies. The horizontal organization found wasn't observed before in other studies using other techniques.
机译：血氧水平依赖性对比（粗体）在α-氯葡萄糖麻醉大鼠的小脑中观察到7T的函数MRI反应，响应于前爪或后爪的无害电刺激。在冠状和矢状切片中对官能进行成像，其允许明确描绘和观察到的激活的定位。我们通过对同一刺激成像并通过显示细胞反应的高水平再现性来证明我们的FMRI协议的有效性。主要是一种主要的双侧活性，主要是一种斑块和Medio-横向频段组织，更明显的同侧。由前爪或后爪刺激引起的小脑激活之间没有重叠。最卓越的是这些响应的整体水平组织：对于刺激范例，激活的斑块和带的斑块和带状粗略地定位在穿过整个小脑后部的颅骨或尾部垂直的颅骨或尾部。这是大鼠小脑中的第一个FMRI研究。我们将我们的研究结果与其他技术和人体FMRI研究的发现结果联系起来。使用其他技术之前在其他研究之前未观察到的水平组织。

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