• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on physiology and function from multidimensional images >Changes during pentetrazol-induced epilepsy in rat recorded by simultaneous EEG/MRI at 7T
【24h】

Changes during pentetrazol-induced epilepsy in rat recorded by simultaneous EEG/MRI at 7T

机译：在7T时通过同时EEG / MRI记录的大鼠诱导癫痫期间的变化

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Simultaneously acquired EEG and BOLD (Blood Oxygenation level dependent contrast) MRI allowed to study on line the neurophysiological changes in rat brain during epileptic seizures. MRI and EEG data were acquired with a specially designed high quality MR RF-antenna with incorporated non- invasive carbon EEG electrodes. The problem of severe pollution of the EEG data due to MR gradient switching during simultaneous EEG/MRI acquisitions was solved by a specially designed automated effective filtering algorithm. We measured continuously EEG data, and T$-2$/*-weighted coronal MRI sections of rat brain before and after the injection of pentetrazol (43 mg/(kg body weight) PTZ; convulsive dose 97%), an epilepsy inductor. In this way, we could correlate the abnormalities in the EEG traces, with changes in the MRI BOLD signal intensities. Immediately after PTZ induction and before epileptic discharges were observed on the EEG traces, the cortex displayed an increase in BOLD signal intensity (increase in blood flow). Much later and correlated with epileptic discharges on the EEG traces, the ventromedial hypothalamic nuclei showed an increased BOLD signal while the BOLD signal intensity dropped in the entire brain, except for the hypothalamus. The decreased BOLD signal reflected general hypoxia and subsequent ischemia as a consequence of the sustained depolarization of neurons during the seizure.
机译：同时获取的EEG和BOLD（血氧水平依赖对比度）允许MRI在线大鼠脑内神经生理变化过程中癫痫发作的研究。 MRI和EEG数据用一专门设计的高质量的MR RF天线与并入非侵入碳EEG电极获得的。所述EEG数据由于MR梯度切换的重度污染的过程中同时进行EEG / MRI采集问题由一个专门设计的自动有效的过滤算法来解决。我们连续测量EEG数据，和T $ $ -2 / * - 大鼠脑冠状加权MRI切片之前和戊四氮的注射后（43毫克/（kg体重）PTZ;惊厥剂量97％），癫痫电感器。这样一来，我们就可以在相关的痕迹脑电图异常，随着MRI BOLD信号强度的变化。 PTZ诱导后，观察在EEG痕迹癫痫放电之前，立即将皮质显示在BOLD信号强度（在血流增加）的增加。晚得多，并与在EEG痕迹癫痫放电相关，腹内侧下丘脑核显示而BOLD信号强度在整个大脑下降，除了下丘脑的增加的BOLD信号。 BOLD信号反射的一般缺氧和随后的局部缺血神经元作为的持续的去极化的发作过程中的结果的降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号