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首页> 外文会议>Conference on physiology and function from multidimensional images >Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI
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Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI

机译：使用体内MRI在大鼠光化学卒中模型中局灶性脑缺血进展的定量表征

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Stroke models, if used in drug evaluation studies, should have a predictable and reproducible course and outcome. While most drug trials focus on the lesion outcome, our study shows the importance of studying lesion growth instead of lesion outcome. In the study reported here, the time course of a photochemically induced neocortical infarct is studied in rats, using diffusion-weighted magnetic resonance imaging, while the rats were submitted to a rigorous control of physiological parameters, ensuring constant body temperature, blood gases (pO$-2$/ and pCO$-2$/), arterial pressure, heart rate and plasma glucose levels. Under such a stable physiological condition, rats were imaged as soon as possible after lesion up to 6 hours, which is the most important period to determine the slope of further lesion growth and final outcome. The data show that the initial size of the lesion is important for the further outcome of the stroke, both in lesion size and severity of the ischemic damage, as reflected by changes in the Apparent Diffusion Coefficient.
机译：中风模型（如果用于药物评估研究），应具有可预测和可重复的课程和结果。虽然大多数药物试验专注于病变结果，但我们的研究表明了研究病变生长而不是病变结果的重要性。在此处报告的研究中，使用扩散加权磁共振成像研究了光化学诱导的新皮肤梗塞的时间过程，同时将大鼠对生理参数进行严谨控制，确保恒定的体温，血液气体（PO $ -2 $ /和PCO $ -2 $ /），动脉压，心率和血浆葡萄糖水平。在这种稳定的生理条件下，大鼠在低至6小时后尽快成像，这是确定进一步病变生长和最终结果的最重要的时间。数据显示，由于表观扩散系数的变化反映，损伤的初始尺寸对于中风的进一步结果，这既不是缺血损伤的病变大小和严重程度。

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