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首页> 外文会议>Proceedings '96 China-Japan symjposium on particuology >EFFECTS OF BINDERS ON GRANULATION
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EFFECTS OF BINDERS ON GRANULATION

机译：粘合剂对成粒的影响

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Effects of kind of the binder and the amount used on the physical characteristics of the particles obtained in granulation were studied. Carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone ( PVP- K30) and L-hydroxypropyl cellulose (HPC-L) were investigated. Parameters related to flowability, particle size distribution and the wearability were determined with the granule particles prepared by incorparating varying amount of the binder into a fixed formula. It was found that the influence of kind of the binder on the quality of the granule was not very marked. However, the amount of the binder was a rather critical factor effecting the flowability of the granule. Good flowability is important for the avoidance of solid bridging of the granule in subsequent processing to get the final pharmaceutical product.
机译：研究了粘合剂的种类和用量对制粒中获得的颗粒的物理特性的影响。研究了羧甲基纤维素（CMC-Na），聚乙烯吡咯烷酮（PVP-K30）和L-羟丙基纤维素（HPC-L）。与流动性，粒度分布和耐磨性有关的参数由通过将不同量的粘合剂掺入固定配方中而制备的颗粒来确定。发现粘合剂种类对颗粒质量的影响不是很明显。然而，粘合剂的量是影响颗粒的流动性的相当关键的因素。良好的流动性对于避免在随后的加工中获得最终药物产品的颗粒的固体桥接是重要的。

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