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Two patterns of macromolecule transport and two patterns of disease at sites of arterial branching

机译：大分子转运的两种模式和动脉分支部位的两种疾病

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Anitschkow and colleagues showed early this century that lipid deposition in the aortas of cholesterol-fed rabbits occurs primarily around the downstream margins of branch sites. They additionally showed that circulating intravital dyes are taken up particularly avidly by the arterial wall in these regions, a localisation that was attributed to mechanical factors. Numerous subsequent studies have shown essentially the same distribution of diet-induced disease, the same pattern of intravital dye uptake, and the same transport pattern for more stable macromolecular tracers. Consequently, the existence of causal links between mechanical stresses, enhanced transport and a high prevalence of disease downstream of branches has become generally accepted. Furthermore, these processes are commonly assumed to apply to human disease despite substantial evidence that such disease can develop at different sites.
机译：Anitschkow及其同事在本世纪初表明，胆固醇喂养的兔子的主动脉中的脂质沉积主要发生在分支部位的下游边缘。他们还表明，在这些区域中，动脉壁特别活跃地吸收了循环中的活体染料，这是由于机械因素引起的。大量后续研究表明，饮食引起的疾病的分布基本相同，体内染料吸收的模式相同，而对于大分子示踪剂来说，其传输模式也相同。因此，机械应力，增强的运输和分支下游疾病的普遍流行之间存在因果关系已被普遍接受。此外，尽管有大量证据表明此类疾病可在不同部位发展，但通常假定这些过程适用于人类疾病。

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