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Effects of microwave irradiation on hippocampal synaptic plasticity in vivo in rats

机译：微波辐射对大鼠海马突触可塑性的影响

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Long-term potentaion (LTP) of hippocampal synaptic activity is by far the most popular and widely researched model of synaptic plastic changes that might occur during leariing. Microwave irradiation cna disrupt cognitive performance in the rat, and increase endogenous opioid activity, which in trun caused a decrease in cholinergic perofrmance in the rat, and increase endogenous opioid activity, whih in turn caused a decrease in cholinergic activity in the brain of the rat (Lai et al., Bioelectromagnetics, 1992, 13:237; 1994, 15:95). In order to investigate the effects of microwave irradiation on the hippocampal synaptic plasticity, LTP of the population spikes (PS) amplitude was employed immediately after the chronic microwave irradiation. LTP was induced in hippocampal dentate gyrous by deliverign weak stimuli (60Hz, 30 pulses) to medial perforant path of urethane-anaesthetized rats, which pretreated by a series of microwave experiments. In the microwave test, the rats were exposed to continuous (245MHz) microwave in seven daily sessions of 60min at 10 mW/cm~2 , 15 mW/cm~2 and 25 mW/cm~2 power densities respectively. Control group was treated on te same condition without microwave irradiation. The data showed that the continous 2450MHz microwave can decrease the induce rate of the PS amplitude LTP: control=85.7
机译：迄今为止，海马突触活动的长期电位（LTP）是最流行和研究最广泛的突触塑化过程中可能发生的模型。微波辐射会破坏大鼠的认知能力，并增加内源性阿片样物质的活性，从而导致大鼠胆碱能的表现降低，并增加内源性阿片样物质的活性，从而导致大鼠脑内的胆碱能的活性下降。 （Lai等人，Bioelectromagnetics，1992，13：237; 1994，15：95）。为了研究微波辐照对海马突触可塑性的影响，在长期微波辐照后立即采用种群峰值（PS）振幅的LTP。 LTP是通过向尿烷麻醉大鼠的内侧穿孔路径传递弱刺激（60Hz，30个脉冲）在海马齿状回旋中诱导的，并通过一系列微波实验对其进行了预处理。在微波测试中，将大鼠连续7天每天60min暴露于连续（245MHz）微波中，功率密度分别为10 mW / cm〜2、15 mW / cm〜2和25 mW / cm〜2。对照组在相同条件下接受微波辐照治疗。数据表明，连续的2450MHz微波可以降低PS振幅LTP的诱导率：控制= 85.7

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