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首页> 外文会议>Asia and South Pacific Design Automation Conference >Hamming-distance-based valve-switching optimization for control-layer multiplexing in flow-based microfluidic biochips
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Hamming-distance-based valve-switching optimization for control-layer multiplexing in flow-based microfluidic biochips

机译：基于汉明远程的阀门切换优化，用于基于流量的微流体Biochips中的控制层复用

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Flow-based microfluidic biochips have progressed significantly in the past decade. Thanks to innovations in multilayer soft lithography (MSL) fabrication technology, the integration of thousands of microvalves along with large-scale networks of microchannels on a chip has been enabled. This progress has even been compared to the evolution of VLSI circuits following Moore's Law. In flow-based microfluidic biochips, microvalves are critical components to control the fluidic transportation for complex operations. To activate the open/close states of a microvalve, off-chip control pins are required. Due to the tremendous increase of the number of microvalves, a software-programmable microfluidic platform has been proposed to reduce the number of off-chip control pins, which integrates a microfluidic multiplexer on a separate control layer to control the array of microvalves. The multiplexer needs to be switched when the states of microvalves are changed between every two adjacent time slots. High switching frequency will make the multiplexer vulnerable and decrease the chip's reliability. We observe that different switching orders of microvalves lead to different switching frequencies of a multiplexer. Based on this observation, this paper proposes the first Hamming-distance-based switching order optimization method for microvalves to enhance the reliability of the multiplexer. Experimental results show that our method can significantly reduce the switching frequency of multiplexer, and the solution is very close to the theoretical optimal lower bound.
机译：在过去十年中，流动型的微流体生物芯片在显着进展。由于多层软光刻（MSL）制造技术的创新，已经启用了数千种微型纤维的集成以及芯片上的大规模微通道网络。这一进展甚至与摩尔定法造成的VLSI电路的演变进行了比较。在基于流动的微流体生物芯片中，微型阀是控制用于复杂操作的流体运输的关键组件。为了激活微型阀的打开/关闭状态，需要片外控制引脚。由于微型阀的数量巨大增加，已经提出了一种软件可编程的微流体平台来减少片外控制引脚的数量，该装置在单独的控制层上集成微流体多路复用器以控制微型阀阵列。当在每个两个相邻的时隙之间改变微型阀的状态时，需要切换多路复用器。高开关频率将使多路复用器易受攻击并降低芯片的可靠性。我们观察到，不同的微型阀的切换订单导致多路复用器的不同开关频率。基于该观察，本文提出了一种用于微型纤维的第一汉明距离的开关顺序优化方法，以增强多路复用器的可靠性。实验结果表明，我们的方法可以显着降低多路复用器的开关频率，解决方案非常接近理论最佳下限。

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