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首页> 外文会议>Asia and South Pacific Design Automation Conference >Hamming-distance-based valve-switching optimization for control-layer multiplexing in flow-based microfluidic biochips
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Hamming-distance-based valve-switching optimization for control-layer multiplexing in flow-based microfluidic biochips

机译：基于汉明距离的阀控切换技术，用于基于流的微流控生物芯片中的控制层多路复用

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Flow-based microfluidic biochips have progressed significantly in the past decade. Thanks to innovations in multilayer soft lithography (MSL) fabrication technology, the integration of thousands of microvalves along with large-scale networks of microchannels on a chip has been enabled. This progress has even been compared to the evolution of VLSI circuits following Moore's Law. In flow-based microfluidic biochips, microvalves are critical components to control the fluidic transportation for complex operations. To activate the open/close states of a microvalve, off-chip control pins are required. Due to the tremendous increase of the number of microvalves, a software-programmable microfluidic platform has been proposed to reduce the number of off-chip control pins, which integrates a microfluidic multiplexer on a separate control layer to control the array of microvalves. The multiplexer needs to be switched when the states of microvalves are changed between every two adjacent time slots. High switching frequency will make the multiplexer vulnerable and decrease the chip's reliability. We observe that different switching orders of microvalves lead to different switching frequencies of a multiplexer. Based on this observation, this paper proposes the first Hamming-distance-based switching order optimization method for microvalves to enhance the reliability of the multiplexer. Experimental results show that our method can significantly reduce the switching frequency of multiplexer, and the solution is very close to the theoretical optimal lower bound.
机译：在过去的十年中，基于流的微流生物芯片取得了显着进展。得益于多层软光刻（MSL）制造技术的创新，芯片上成千上万个微阀以及大规模微通道网络的集成得以实现。甚至可以将这一进展与遵循摩尔定律的VLSI电路的发展进行比较。在基于流量的微流控生物芯片中，微阀是控制复杂操作的流体输送的关键组件。为了激活微阀的打开/关闭状态，需要片外控制引脚。由于微阀数量的巨大增加，已经提出了一种软件可编程的微流体平台来减少芯片外控制引脚的数量，该平台将微流体多路复用器集成在单独的控制层上以控制微阀阵列。当微阀的状态在每两个相邻的时隙之间改变时，需要切换多路复用器。高开关频率将使多路复用器易受攻击，并降低芯片的可靠性。我们观察到微阀的不同开关顺序导致了多路复用器的不同开关频率。基于这种观察，本文提出了第一种基于汉明距离的微阀切换顺序优化方法，以提高多路复用器的可靠性。实验结果表明，我们的方法可以大大降低多路复用器的开关频率，并且该解决方案非常接近理论上的最佳下限。

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