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CHEMICALLY BONDED BIOCERAMIC CARRIER SYSTEMS FOR DRUG DELIVERY

机译:用于药物递送的化学键合生物陶瓷载体系统

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This paper deals with carrier materials for drug delivery based on chemically bonded ceramics (CBC), and specifically Ca-aluminates (CA). The property profile of these CBC-biomaterials and their microstructures give these materials potential as carriers for drugs. The paper describes in some detail the CA carrier system with regard to the technology and chemistry, the biocompatibility and specifically the microstructure and the related loading possibilities of the drugs in the carrier material. The development of microstructures includes different types of porosity, amount of porosity, pore size and pore channel size, and combination of different porosity structures. Specific surface area measurements (BET) of dried fully hydrated Ca-aluminate yield BET- values of > 400 m~2 /g, corresponding to a hydrate size of approximately 25 nm, and pore channel sizes of 1-10 nm, in accordance with values from the high-resolution TEM analysis. Complementary porosity above 10 nm is obtained by partial hydration of the precursor material or excess of water in the hydration step, and pore sizes > 100 nm by inert ceramic fillers with phases of oxides of Ti, Si, Ba or Zr, the latter phases selected in order also to increase strength and radio-opacity of the carrier systems discussed. The carrier material can be applied as a solid or a suspension for different types of intake. The drug carrier can also work as an injectable implant.
机译:本文涉及基于化学键合陶瓷(CBC)的药物递送的载体材料,特别是Ca-铝酸盐(CA)。这些CBC-生物材料的性质谱及其微观结构使这些材料成为药物的载体。本文在一些细节中描述了CA载体系统关于技术和化学,生物相容性,具体地是载体材料中药物的微观结构和相关的负载可能性。微观结构的发展包括不同类型的孔隙率,孔隙率,孔径和孔径尺寸,以及不同孔隙率结构的组合。干燥完全水合的Ca-铝酸盐产率的比表面积(BET)> 400m〜2 / g的值,对应于约25nm的水合物尺寸,孔径尺寸为1-10nm,按照高分辨率TEM分析的值。通过在水合步骤中的前体材料或过量的水的部分水合理获得10nm以上的互补孔隙,并且通过惰性陶瓷填料,孔径尺寸> 100nm具有Ti,Si,Ba或Zr的氧化物相,所以后阶段还为了增加讨论的承运人系统的强度和无透明度。载体材料可以作为固体或悬浮​​液用于不同类型的摄入量。药物载体还可以作为可注射植入物的用作。

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