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首页> 外文会议>Advances in bioceramics and porous ceramics III >CHEMICALLY BONDED BIOCERAMIC CARRIER SYSTEMS FOR DRUG DELIVERY
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CHEMICALLY BONDED BIOCERAMIC CARRIER SYSTEMS FOR DRUG DELIVERY

机译：化学结合的生物陶瓷载体系统，用于药物输送

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This paper deals with carrier materials for drug delivery based on chemically bonded ceramics (CBC), and specifically Ca-aluminates (CA). The property profile of these CBC-biomaterials and their microstructures give these materials potential as carriers for drugs. The paper describes in some detail the CA carrier system with regard to the technology and chemistry, the biocompatibility and specifically the microstructure and the related loading possibilities of the drugs in the carrier material. The development of microstructures includes different types of porosity, amount of porosity, pore size and pore channel size, and combination of different porosity structures. Specific surface area measurements (BET) of dried fully hydrated Ca-aluminate yield BET- values of > 400 m~2 /g, corresponding to a hydrate size of approximately 25 nm, and pore channel sizes of 1-10 nm, in accordance with values from the high-resolution TEM analysis. Complementary porosity above 10 nm is obtained by partial hydration of the precursor material or excess of water in the hydration step, and pore sizes > 100 nm by inert ceramic fillers with phases of oxides of Ti, Si, Ba or Zr, the latter phases selected in order also to increase strength and radio-opacity of the carrier systems discussed. The carrier material can be applied as a solid or a suspension for different types of intake. The drug carrier can also work as an injectable implant.
机译：本文涉及基于化学键合陶瓷（CBC），特别是铝酸钙（CA）的药物输送载体材料。这些CBC生物材料的性质特征及其微结构使这些材料具有作为药物载体的潜力。本文就CA载体系统的技术和化学，生物相容性，尤其是药物的微观结构以及相关的药物在载体材料中的负载可能性进行了详细描述。微观结构的发展包括不同类型的孔隙度，孔隙量，孔径和孔道尺寸，以及不同孔隙结构的组合。干燥的完全水合铝酸钙的比表面积（BET）值> 400 m〜2 / g，对应于大约25 nm的水合物尺寸和1-10 nm的孔道尺寸高分辨率TEM分析得到的数值。通过在水合步骤中对前体材料进行部分水合或过量的水来获得高于10 nm的互补孔隙率，并通过具有Ti，Si，Ba或Zr氧化物相的惰性陶瓷填料进行孔径大于100 nm的孔径选择为了增加所讨论的载体系统的强度和不透射线性。载体材料可以固体或悬浮​​液形式用于不同类型的摄入。药物载体也可以用作可注射植入物。

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