• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Asian Particle Technology Symposium >A novel method for preparing nanoparticles of medicinal substances using supercritical carbon dioxide
【24h】

A novel method for preparing nanoparticles of medicinal substances using supercritical carbon dioxide

机译：一种新的超临界二氧化碳制备药物纳米粒子的方法

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: The purpose of this study is to demonstrate a novel method for preparing nanoparticles of active pharmaceutical ingredients using a continuous system under supercritical carbon dioxide (scCO2) conditions.Methods: An improved system using rapid expansion from supercritical to aqueous solution (RESAS) method was used in order to prepare nanoparticles of medicinal substances. Indomethacin (IMC) was used as a model compound. The scCO2 mixed with a suitable amount of solution of IMC in ethanol was expanded into water. The resultant aqueous suspension was freeze dried, and then powder properties of freeze dried samples were evaluated by particle size, crystallinity, scanning electron microphotograph, and inhalation study.Results: When the solution of IMC in ethanol was sprayed into the vessel of scCO2 at the relatively lower CO2 pressure as 10 MPa at 40 C, a large amount of IMC was precipitated in the vessel. In this case, scCO2 might behave as an antisolvent as reported by the supercritical antisolvent precipitation technique. On the other hand, no precipitation of IMC was observed in the vessel if the CO2 pressure was higher than 15 MPa at 40 C. This finding suggested that the solution of IMC in ethanol was dispersed or dissolved in the high pressured CO2 fluid. When the CO2 fluid containing IMC and ethanol was expanded into water, nanoparticles of IMC were produced. The freeze dried sample of the suspension showed a good redispersibility in water to form a nanoparticle suspension. The particle size of IMC after dispersed varied depending on CO2 pressure and temperature in the vessel. At the optimum conditions, as 25 MPa at 40 C, nanoparticles of IMC (around 350 run) were obtained. The freeze dried powders exhibited mass median diameters in air about 4 μm. Consequently, the freeze dried powders obtained under the optimum conditions showed good inhalation properties compared to the untreated IMC.Conclusions. This method produces fine crystals of IMC with a high yield. The freeze dried sample from IMC suspension shows both a good redispersibility into water and a good inhalation property. Therefore, this method may be promising in developing novel dry powder inhalation forms.
机译：目的：本研究的目的是通过在超临界二氧化碳（SCCO2）条件下使用连续系统制备活性药物成分的纳米颗粒的目的。方法：使用超临界到水溶液（Resas）方法的快速膨胀的改进系统用于制备药物纳米颗粒的纳米颗粒。吲哚美辛（IMC）用作模型化合物。将与合适量的IMC溶液混合在乙醇中的SCCO 2膨胀成水。将所得含水悬浮液冷冻干燥，然后通过粒度，结晶度，扫描电子显微照片和吸入研究评估冷冻干燥样品的粉末性能。结果：当在乙醇中的IMC溶液喷洒到SCCO2的血管中时在40℃下相对较低的CO 2压力为10MPa，在容器中沉淀大量IMC。在这种情况下，SCCO2可能表现为由超临界抗溶解技术报道的抗溶剂。另一方面，如果CO 2压力高于40℃，则在容器中没有观察到IMC的沉淀。该发现表明，将IMC在乙醇中的溶液分散或溶解在高压CO 2流体中。当含有IMC和乙醇的CO 2流体膨胀到水中时，产生了IMC的纳米颗粒。悬浮液的冷冻干燥样品在水中显示出良好的再分散性以形成纳米颗粒悬浮液。分散后IMC的粒径根据CO 2压力和容器中的温度而变化。在最佳条件下，在40℃下为25MPa，获得IMC的纳米颗粒（约350次）。冷冻干燥的粉末在空气中显示出约4μm的质量中值直径。因此，与未处理的IMC.Conclusions相比，在最佳条件下获得的冷冻干燥粉末显示出良好的吸入性质。该方法产生具有高产的IMC的细晶体。来自IMC悬浮液的冷冻干燥样品显示出水中的良好重新分配和良好的吸入性。因此，该方法可能在开发新型干粉吸入形式方面具有很大。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号