Non-viral gene delivery of polyplexed with nanoparticles transfected into MSCs

机译：与纳米颗粒转染到MSCs中的复合体的非病毒基因传递

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Human mesenchymal stem cells (hMSCs) represent a potent target for gene delivery for both stem cell differentiation applications and clinical therapies. We have evaluated different vehicles with regard to the efficiency with which they deliver hMSCs and enhance the ability to deliver a reporter gene. In this study, a nonviral gene delivery system using nanoparticles was designed, with emphasis placed on the ability of the system to mediate high levels of gene expression into stem cells.

机译：人间充质干细胞（hMSCs）代表了用于干细胞分化应用和临床治疗的基因传递的有效靶标。我们已经评估了不同媒介物传递hMSCs的效率，并增强了传递报告基因的能力。在这项研究中，设计了使用纳米颗粒的非病毒基因递送系统，重点是该系统介导高水平基因表达进入干细胞的能力。

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《Annual meeting exposition of the Controlled Release Society》|2011年|p.782-783|共2页
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Ji Sun Park; Keun-Hong Park;
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中图分类系统科学;
关键词
hMSC; Nanoparticles; PEI; GFP;

机译：骨髓间充质干细胞纳米颗粒; PEI;绿色荧光蛋白;

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专利

1. Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells. [J] . Park JS, Na K, Woo D Biomaterials . 2010,第1期

机译：DNA的非病毒基因递送与转染到人间充质干细胞中的纳米颗粒复合。
2. Biodegradable capsules as non-viral vectors for in vitro delivery of PEI/siRNA polyplexes for efficient gene silencing [J] . Ganas Carolin, Weiss Annika, Nazarenus Moritz, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2014,第Null期

机译：可生物降解的胶囊作为非病毒载体，用于体外递送PEI / siRNA复合物以实现有效的基因沉默
3. Non-viral polyplexes: Scaffold mediated delivery for gene therapy [J] . Suzanne ORorke, Michael Keeney, Abhay Pandit Progress in Polymer Science . 2010,第4期

机译：非病毒复合物：支架介导的基因治疗递送
4. Immobilization of His-tagged polyplexes to Ni-NTA Self-assembled Monolayers for Non-viral Gene Delivery from Surfaces [C] . Chung-Huei K. Wang, Shaoyi Jiang, Suzie H. Pun Annual meeting exposition of the Controlled Release Society . 2011

机译：将带有His标签的多链体固定在Ni-NTA自组装单分子膜上，用于从表面传递非病毒基因
5. Optimization of a Biomimetic Apatite Nanoparticle Delivery System for Non-viral Gene Transfection---a Simulated Body Fluid Approach. [D] . Das, Debobrato. 2013

机译：用于非病毒基因转染的仿生磷灰石纳米颗粒递送系统的优化-一种模拟体液方法。
6. Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis [O] . William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, 2020

机译：使用胶原羟基磷灰石支架的白细胞介素-1受体拮抗剂的非病毒基因递送免受IL-1β介导的大鼠BM-MSCs的抑制作用
7. Non-viral gene delivery: Multifunctional polyplexes as locally triggerable nonviral vectors [O] . J A Hubbell 2006

机译：非病毒基因递送：多功能的多用途，作为局部可引发的非血管载体

Non-viral gene delivery of polyplexed with nanoparticles transfected into MSCs

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