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Synthesis and Characterization of PEG-Iron Oxide Core-shell Nanoparticles for Cancer Therapy

机译:聚乙二醇氧化铁核壳纳米粒子的合成与表征

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ATRP was successfully utilized to coat iron oxide nanoparticles with a PEG based polymer shell. For the time frame of the thermal therapy experiments, there is a minimal toxic effect observed in A549 cells for the 15 mg/ml concentration of PEG-coated Fe_3O_4 nanoparticles. Thermoablation of A549 demonstrates the potential use of polymer coated particles for thermal therapy. Future work involves the refinement of the dual therapy study to demonstrate a synergistic effect of a co-delivery of paclitaxel and hyperthermia from magnetic nanoparticles.
机译:ATRP被成功地利用基于PEG的聚合物外壳包覆氧化铁纳米颗粒。对于热疗法实验的时间范围,对于15 mg / ml浓度的PEG包覆的Fe_3O_4纳米粒子,在A549细胞中观察到的毒性作用最小。 A549的热消融证明了聚合物涂层颗粒在热疗法中的潜在用途。未来的工作涉及对双重疗法研究的改进,以证明紫杉醇和磁性纳米粒子共同递送紫杉醇和热疗的协同作用。

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