Dynamics of HBV model with intermittent antiviral therapy

机译：间歇性抗病毒治疗的HBV模型动力学

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This paper studies the dynamics of the Hepatitis B virus (HBV) model with intermittent antiviral therapy. We first propose a mathematical model of HBV and then analyze its qualitative and dynamical properties with a new treatment therapy. Combining with the clinical data and theoretical analysis, we show that the intermittent antiviral therapy regimen is one of optimal strategies to treat this kind of complex disease. There are two mainly advantages on this therapy. Firstly, it can delay the drug resistance. Secondly, it can reduce the duration of treatment time comparing with the long term continuous therapy, thereby reducing the adverse side effect. Our results clear provides a new way to treat the HBV disease.

机译：本文研究了间歇性抗病毒治疗的乙型肝炎病毒（HBV）模型的动力学。我们首先提出了乙型肝炎病毒的数学模型，然后通过一种新的治疗方法分析了乙型肝炎病毒的定性和动力学特性。结合临床资料和理论分析，我们表明间歇性抗病毒治疗方案是治疗这种复杂疾病的最佳策略之一。这种疗法有两个主要优点。首先，它可以延迟耐药性。其次，与长期连续治疗相比，它可以减少治疗时间，从而减少不良副作用。我们的结果清楚地提供了治疗HBV疾病的新方法。

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《2011 IEEE International Conference on Systems Biology》|2011年|p.244-248|共5页
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Ben-gong Zhang; Luonan Chen; Aihara Kazuyuki;
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中图分类生物工程学（生物技术）;
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1. Dynamics of an HBV Model with Drug Resistance Under Intermittent Antiviral Therapy [J] . Zhang Ben-Gong, Tanaka Gouhei, Aihara Kazuyuki, International journal of bifurcation and chaos in applied sciences and engineering . 2015,第7期

机译：间歇性抗病毒治疗下耐药性HBV模型的动力学
2. Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy [J] . Allice T, Cerutti F, Pittaluga F, The New Microbiologica . 2008,第1期

机译：抗病毒治疗期间Cobas Ampliprep / Cobas TaqMan HBV测试与Cobas Amplicor HBV监测仪在HBV-DNA检测和定量分析中的比较
3. Comparison of the cobas Ampliprep (TM)/Cobas TaqMan (TM) HBV test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy [J] . Allice Tiziano, Cerutti Francesco, Pittaluga Fabrizia, The New Microbiologica . 2008,第1期

机译：Cobas Ampliprep（TM）/ Cobas TaqMan（TM）HBV测试与Cobas Amplicor HBV监测仪在抗病毒治疗期间用于HBV-DNA检测和定量的比较
4. Dynamics of HBV model with intermittent antiviral therapy [C] . Ben-gong Zhang, Luonan Chen, Aihara Kazuyuki IEEE International Conference on Systems Biology . 2011

机译：间歇抗病毒治疗HBV模型的动态
5. Mathematical Models of Androgen Resistance in Prostate Cancer Patients under Intermittent Androgen Suppression Therapy [D] . Baez, Javier. 2017

机译：间歇性雄激素抑制治疗前列腺癌患者雄激素抗性的数学模型
6. Effects of antiviral therapy on post-hepatectomy HBV reactivation and liver function in HBV DNA-negative patients with HBV-related hepatocellular carcinoma [O] . Wen-Feng Gong, Jian-Hong Zhong, Shi-Dong Lu, 2017

机译：抗病毒治疗对HBV相关肝细胞癌HBV DNA阴性患者肝切除术后HBV活化和肝功能的影响
7. Effects of transarterial chemoembolization combined with antiviral therapy on HBV reactivation and liver function in HBV-related hepatocellular carcinoma patients with HBV-DNA negative [O] . Kai Wang, Guomin Jiang, Zhongzhi Jia, 2018

机译：静脉化疗栓塞与抗病毒治疗对HBV相关肝癌患者HBV再活化和肝功能的影响
8. Enhancement of Intermittent Androgen Ablation Therapy by Finasteride Administration in Animal Models. [R] . Wang, Z. 2006

机译：动物模型中非那雄胺给药增强间歇性雄激素消融治疗。

Dynamics of HBV model with intermittent antiviral therapy

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