Image processing challenges in the creation of spatiotemporal gene expression atlases of developing embryos

机译：发育中的胚胎的时空基因表达图谱创建中的图像处理挑战

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To properly understand and model animal embryogenesis it is crucial to obtain detailed measurements, both in time and space, about their gene expression domains and cell dynamics. Such challenge has been confronted in recent years by a surge of atlases which integrate a statistically relevant number of different individuals to get robust, complete information about their spatiotemporal locations of gene patterns. This paper will discuss the fundamental image analysis strategies required to build such models and the most common problems found along the way. We also discuss the main challenges and future goals in the field.

机译：为了正确地理解和建模动物胚胎发生，至关重要的是在时间和空间上获得有关其基因表达域和细胞动力学的详细测量。近年来，地图集的涌现正面临着这样的挑战，这些地图集整合了统计学上相关数量的不同个体，以获得有关其基因模式时空位置的可靠，完整的信息。本文将讨论构建此类模型所需的基本图像分析策略以及在此过程中发现的最常见问题。我们还将讨论该领域的主要挑战和未来目标。

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《33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society》|2011年|p.6841-6844|共4页
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Castro Carlos; Luengo-Oroz Miguel Angel; Douloquin Louise; Savy Thierry; Melani Camilo; Desnoulez Sophie; Bourgine Paul; Peyrieras Nadine; Ledesma-Carbayo Maria Jesus; Santos Andres;
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中图分类生物工程学（生物技术）;
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1. Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene expression in the developing C. elegans embryo [J] . Zafer Aydin, John I Murray, Robert H Waterston, BMC Bioinformatics . 2010,第1期

机译：使用机器学习来加快手动图像注释：应用于3D成像协议以测量秀丽隐杆线虫胚胎中单细胞基因的表达
2. Image processing and analysis for quantifying gene expression from early Drosophila embryos [J] . AyA., FakhouriW.D., ChiuC., Tissue engineering, Part A . 2008,第9期

机译：图像处理和分析用于定量果蝇早期胚胎的基因表达
3. Four-dimensional imaging and quantification of gene expression in early developing zebrafish (Danio rerio) embryos. [J] . Yu RM, Lin CC, Chan PK, Toxicological sciences: An official journal of the Society of Toxicology . 2006,第2期

机译：早期发育中的斑马鱼（达尼奥里约）胚胎的基因表达的四维成像和定量。
4. Image processing challenges in the creation of spatiotemporal gene expression atlases of developing embryos [C] . Castro Carlos, Luengo-Oroz Miguel Angel, Douloquin Louise, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：图像处理挑战在制育胚胎的时空基因表达式地图集
5. Content-based image analysis techniques and biological validation schemes for images depicting spatial gene expression patterns in developing embryos. [D] . Gargesha, Madhusudhana. 2006

机译：基于内容的图像分析技术和生物学验证方案，用于描述发育中的胚胎中空间基因表达模式的图像。
6. Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene expression in the developing C. elegans embryo [O] . Zafer Aydin, John I Murray, Robert H Waterston, 2010

机译：使用机器学习来加快手动图像注释：应用于3D成像协议中以测量发育中的秀丽隐杆线虫胚胎中的单细胞基因表达
7. Image processing challenges in the creation of spatiotemporal gene expression atlases of developing embryos. [O] . Castro, Carlos, Luengo-Oroz, Miguel Ángel, Duloquin, Louise, 2011

机译：图像处理对发育中的胚胎的时空基因表达图谱的创建提出了挑战。
8. Murine Hox-2.3 Gene: Expression and Regulation in Embryos (Hox-2.3 Gen in deMuis: Expressie en Regulatie in Embryo's) [R] . Vogels, R. 1992

机译：小鼠Hox-2.3基因：胚胎中的表达和调节（demuis中的Hox-2.3 Gen：胚胎中的表达和调节）

Image processing challenges in the creation of spatiotemporal gene expression atlases of developing embryos

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