Insights into binding modes of μ-opioid receptor agonists and antagonists with pharmacophore model and docking methods

机译：用药效团模型和对接方法洞察μ阿片受体激动剂和拮抗剂的结合模式

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Opioid receptors belong to the rhodopsin subclass within the superfamily of G protein-coupled receptors,which are characterized by the presence of seven transmembrane (TM) helices.They play an important role in controlling pain and stress,modulating immune responses and developing addiction of human body.The interactive mechanism of opioid receptors with ligands is still unclear.In this study,pharmacophore model and molecular docking methods were used to investigate the binding modes of μ-opioid receptor with agonists and antagonists.

机译：阿片类受体属于G蛋白偶联受体超家族中的视紫红质亚类，其特征是存在7个跨膜（TM）螺旋。它们在控制疼痛和压力，调节免疫应答和发展人类成瘾性方面起着重要作用。阿片受体与配体的相互作用机理尚不清楚。本研究采用药效团模型和分子对接方法研究了μ-阿片受体与激动剂和拮抗剂的结合方式。

著录项

来源
《International conference of molecular simulations and applied informatics technologies》|2012年|308-309|共2页
会议地点
作者
Juniie Ding; Xiaoqin Ding; Dayu Li; Jisheng Chen;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类生物工程学（生物技术）;
关键词

相似文献

外文文献
中文文献
专利

1. Three-dimensional model of the human urotensin-II receptor: docking of human urotensin-II and nonpeptide antagonists in the binding site and comparison with an antagonist pharmacophore model. [J] . Lescot E, Sopkova-de-Oliveira-Santos J, Colloch N, Proteins: Structure, Function, and Genetics . 2008,第1期

机译：人尿素II受体的三维模型：人尿素II和非肽拮抗剂在结合位点的对接，并与拮抗剂药效团模型进行比较。
2. Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations. [J] . Lavecchia A, Greco G, Novellino E, Journal of Medicinal Chemistry . 2000,第11期

机译：使用基于药效团和对接的模拟来模拟κ阿片受体/激动剂的相互作用。
3. Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: Application of the 'message-address' concept in development of mu opioid receptor selective antagonists [J] . ZaidiS.A., ArnattC.K., HeH., Bioorganic and medicinal chemistry . 2013,第21期

机译：通过停泊在阿片样物质受体晶体结构和定点诱变研究中的6α-和6β-N-杂环取代的纳曲胺衍生物的结合模式表征：“消息地址”概念在开发阿片类阿片受体选择性拮抗剂中的应用
4. Insights into binding modes of μ-opioid receptor agonists and antagonists with pharmacophore model and docking methods [C] . Juniie Ding, Xiaoqin Ding, Dayu Li, International conference of molecular simulations and applied informatics technologies . 2012

机译：与药物光线模型和对接方法的μ-ApiOID受体激动剂和拮抗剂的结合模式见解
5. Design, synthesis and docking models of estrogen and androgen receptor antagonists. [D] . Tinder, Robert J. 2010

机译：雌激素和雄激素受体拮抗剂的设计，合成和对接模型。
6. Binding Mode Characterization of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives via Docking in Opioid Receptor Crystal Structures and Site-directed Mutagenesis Studies: Application of the Message–Address Concept in Development of Mu Opioid Receptor Selective Antagonists [O] . Saheem A. Zaidi, Christopher K. Arnatt, Hengjun He, -1

机译：通过对接阿片受体晶体结构和定点诱变研究的6α-和6β-N-杂环取代的纳曲胺衍生物的结合模式表征：消息-地址概念在Mu阿片受体选择性拮抗剂的开发中的应用
7. Plasmon Resonance Studies of Agonist/Antagonist Binding to theHuman δ-Opioid Receptor: New Structural Insights into Receptor-Ligand Interactions [O] . Salamon Z., Cowell S., Varga E., 2000

机译：激动剂/拮抗剂与人δ阿片受体的等离子共振研究：受体-配体相互作用的新结构见解。

Insights into binding modes of μ-opioid receptor agonists and antagonists with pharmacophore model and docking methods

摘要

著录项

相似文献

相关主题

期刊订阅