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Physical Properties of Hydrogel Prepared from Stereo Complex of Star-Shaped PEG-Polylactide Block Copolymers Exhibiting Temperature-Responsive Sol-Gel Transition as Cellular Scaffold for Tissue Engineering

机译:由星形粘棒嵌段共聚物的立体复合物制备水凝胶的物理性质,其表现出温度响应溶胶 - 凝胶转变作为组织工程的细胞支架

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Starburst triblock copolymers consisting of 8-arm poly(ethylene glycol) (8-arm PEG), poly(L-lactide) (PLLA) or its enantiomer poly(D-lactide) (PDLA) and terminal PEG, 8-arm PEG-b-PLLA-b-PEG (Stri-L) and 8-arm PEG-b-PDLA-b-PEG (Stri-D), were synthesized. An aqueous solution of a 1:1 mixture (Stri-Mix) of Stri-L and Stri-D assumed a sol state at room temperature, but instantaneously formed a physically cross-linked hydrogel in response to increasing temperature. The resulting hydrogel exhibited a high storage modulus at 37 ?°C. The rapid temperature-triggered hydrogel formation, high mechanical strength, and degradation behavior render this polymer system suitable for use in injectable drug delivery system or a biodegradable scaffold for tissue engineering.
机译:Starburst三嵌段共聚物,由8臂聚(乙二醇)(8臂PEG),聚(L-丙交酯)(PLLA)或其对映体聚(D-丙交酯)(PDLA)和端子PEG,8臂PEG-组成的共聚物组成。合成B-PLLA-B-PEG(Stri-1)和8臂PEG-B-PDLA-B-PEG(Stri-D)。 STRI-L和STRRE-D的1:1混合物(Stri-mix)的水溶液在室温下假设溶胶状态,但响应于升高的温度瞬时形成物理交联的水凝胶。所得水凝胶在37℃下表现出高储存模量。快速触发的水凝胶形成,高机械强度和降解行为使得该聚合物系统适用于可注射药物输送系统或可生物降解的组织工程支架。

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