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首页> 外文会议>International IEEE/EMBS Conference on Neural Engineering >Modulations in pallidal local field potentials in the systemic 1-methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine nonhuman primate model of Parkinson's disease during a voluntary reaching task
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Modulations in pallidal local field potentials in the systemic 1-methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine nonhuman primate model of Parkinson's disease during a voluntary reaching task

机译：自愿达到任务期间全身性1-​​甲基-4-苯基-1、2、3、6-四氢吡啶非人类灵长类帕金森氏病模型中的苍白局部场电位的调节

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摘要

This case-study characterizes the changes in neuronal activity that occur within the globus pallidus (GP) in the behaving systemic l-methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine (MPTP) nonhuman primate model of Parkinson's disease (PD) while on and off dopaminergic therapy. Local field potentials (LFP) were recorded from a scaled 8-contact deep brain stimulation (DBS) lead during a center-out reaching task. Spectral LFP activity and reach behavior were correlated with parkinsonian motor signs and changes in behavior during dopaminergic treatment. Dopamine therapy i) increased reaction time and decreased reach time, ii) shortened the onset-times of LFP synchronization and desynchronization during reaction time, and iii) eliminated desynchronization of the high beta band. These findings suggest that dopamine-induced improvement in bradykinesia is related to a change in the pattern of synchronized oscillatory activity in GP.
机译：该案例研究的特征是帕金森氏病的全身性1-​​甲基-4-苯基-1、2、3、6-四氢吡啶（MPTP）非人类灵长类动物模型（PTP）在苍白球（GP）内发生的神经元活性变化（ PD），同时进行多巴胺能疗法的开和关。在中心向外触碰任务期间，从比例缩放的8接触式深脑刺激（DBS）导线中记录了局部场电势（LFP）。频谱LFP活性和触及行为与帕金森氏运动体征以及多巴胺能治疗期间的行为变化相关。多巴胺疗法i）增加反应时间，减少到达时间，ii）缩短了反应期间LFP同步和失步的开始时间，iii）消除了高β波段的失步。这些发现表明，多巴胺引起的运动迟缓的改善与GP中同步振荡活动模式的改变有关。

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