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首页> 外文会议>International IEEE/EMBS Conference on Neural Engineering >The impact of dual tasking on cognitive performance in a Parkinson's disease cohort with and without freezing of gait: An EEG and behavioral based approach
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The impact of dual tasking on cognitive performance in a Parkinson's disease cohort with and without freezing of gait: An EEG and behavioral based approach

机译：双重任务对帕金森病群体的认知性能与步态冻结的影响：脑电图和行为基于行为的方法

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Freezing of gait (FOG) is a common disabling gait disorder in late stage Parkinson's disease (PD), which can lead to falls and loss of independence. To date, the mechanisms causing FOG are still unknown and no treatment has proven to be effective. In this study, sixteen PD participants with and without clinically confirmed FOG symptoms were recruited, referred to as FOG+ and FOG-, respectively. All participants navigated through a customized virtual reality (VR) corridor by stepping in place (SIP) on a force plate while electroencephalography (EEG) data was recorded. The VR environment was combined with a cognitive, visual two-stimulus oddball response task, which was repeated while seated to allow for comparisons to the SIP condition. The VR environment proved to be a reliable tool to elicit FOG like symptoms in a clinical test environment. EEG recordings were compared between conditions (seated/SIP) within groups and behavioral performance was compared between groups and conditions for qualitative differences. In the seated condition FOG+ participants showed similar behavioral performance to FOG- participants, however, in the SIP condition the FOG+ group showed significantly decreased performance with longer reaction times and more target misses. Analysis of the EEG data revealed consistent visual responses to the stimuli, but an absence of the P3b component in stimulus-locked brain responses for FOG+ participants and both conditions. However, if data is response-locked, the P3b component is clearly visible for both conditions, supporting the theory that components related to decision making and motor preparation are present, but with variable delays.
机译：步态（雾）冷冻是晚期帕金森病（PD）的常见致命性障碍，这可能导致独立性下降和失去独立性。迄今为止，导致雾的机制仍然是未知的，并且没有证据证明是有效的。在这项研究中，招募了16名有没有临床证实雾症状的PD参与者，分别被称为雾+和雾。所有参与者通过定制虚拟现实（VR）走廊通过在脑电图（EEG）数据被记录时踩在力板上（SIP）进行踩踏（SIP）。 VR环境与认知，视觉双刺激壁垒响应任务组合，在坐着的同时重复，以允许与SIP条件进行比较。 VR环境证明是一种可靠的工具，可以在临床测试环境中引出症状的雾化。 eeg录像在组内（坐在/ sip）之间比较，并且在分组之间比较了行为性能与定性差异的条件之间。在坐下的情况下，雾+参与者对雾化者表现出类似的行为性能，然而，在SIP条件下，雾+组表现出显着降低的性能与更长的反应时间和更多目标未命中。 EEG数据的分析显示对刺激的一致视觉响应，而是对雾+参与者和两个条件的刺激锁重脑反应中的P3B组分的不存在。但是，如果数据响应锁定，则P3B组件对于这两个条件清晰可见，支持存在与决策和运动准备相关的组件，但具有可变延迟。

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