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首页> 外文会议>IEEE International Conference on Nano/Micro Engineered and Molecular Systems >Finite element simulation of stress relaxation process in living cells
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Finite element simulation of stress relaxation process in living cells

机译：活细胞应力松弛过程的有限元模拟

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In this manuscript, we investigated the fundamental mechanism of stress relaxation phenomenon by employing finite element simulation. Through finite element simulations, the evolution of stress distribution, deformation field and the interaction force was wholly recorded during both the loading and stress relaxation stages. With the developed simulation model, the sensitivity of force-time curves on cell height and substrate stiffness was thoroughly studied by changing the thickness of cell and Young's modulus of the substrate. The simulation results indicated that the variation of cell height leads to the significant change of F-t curve's magnitude but tiny deviation of the curve's shape. And the influence originates from the substrate can be totally eliminated with relatively hard substrate. Finally, using the viscoelastic parameters extracted from actual stress relaxation experiment, the dynamic mechanical behavior of L929 cells is simulated and investigated. A comparison between the experimental and simulation F-t curves demonstrated the effectiveness of the proposed finite element simulation approach.
机译：在这个手稿中，我们通过采用有限元模拟来研究压力松弛现象的基本机制。通过有限元模拟，在负载和应力松弛阶段期间，应力分布，变形场和相互作用力的演变。利用开发的仿真模型，通过改变基板的细胞和杨氏模量的厚度来彻底研究了电池高度和基板刚度的力 - 时间曲线的敏感性。仿真结果表明，电池高度的变化导致F-T曲线幅度的显着变化，但曲线形状的微小偏差。并且可以通过相对硬的基材完全消除影响源自基质。最后，使用从实际应力松弛实验中提取的粘弹性参数，模拟和研究了L929细胞的动态力学行为。实验和仿真F-T曲线之间的比较证明了提出的有限元模拟方法的有效性。

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