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Adaptive window selection in estimating dynamic functional connectivity of resting-state fMRI

机译：估算静态静态FMRI动态功能连通性的自适应窗口选择

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Investigation of the intrinsic brain networks using the resting-state functional magnetic resonance imaging (rs-fMRI) is generally based on the assumption that the functional organization is stationary across the duration of the scan. Hence, the presence and potential of temporal and spatial dynamics of the functional connectivity (FC), which is usually measured by the correlation coefficients between rs-fMRI signals of two regions, are not taken into account in most of the research. Recent studies have shown that the resting-state brain activities are time-varying in nature with substantial dynamic characteristics. However, an effective method for estimating the time-varying FC is lacking, which is mainly due to the difficulty in choosing an appropriate window to localize the time-varying correlation coefficients (TVCC). In this paper, we introduce a novel method for adaptively estimating the TVCC of non-stationary signals and study its application to infer dynamic FC of rs-fMRI data. The proposed method employs a sliding window with adaptive size, which is selected by a local plug-in rule to minimize the mean square error, to estimate the TVCC locally. Simulation results on synthetic data show that the proposed method outperforms the conventional TVCC estimators with a fixed window. Furthermore, the proposed method is used on real rs-fMRI signals, and the results demonstrate that the FC in the resting state are transient and the variability of FCs between different brain regions differs substantially.
机译：使用静止状态功能磁共振成像（RS-FMRI）对内在脑网络的研究通常基于功能组织在扫描持续时间内静止的假设。因此，在大多数研究中，不考虑通过两个区域的RS-FMRI信号之间的相关系数测量的功能连接（FC）的存在和潜力。最近的研究表明，静止状态的大脑活动与具有大量动态特性的性质上的时变。然而，缺乏用于估计时变FC的有效方法，这主要是由于难以选择适当的窗口来定位时变相关系数（TVCC）。在本文中，我们介绍了一种新的方法，用于自适应地估计非静止信号的TVCC，并研究其应用于推断RS-FMRI数据的动态FC。所提出的方法采用具有自适应尺寸的滑动窗口，由本地插件规则选择，以最小化平均方误差，以便本地估计TVCC。合成数据的仿真结果表明，所提出的方法优于具有固定窗口的传统TVCC估计器。此外，所提出的方法用于真实的RS-FMRI信号，结果表明，静止状态下的FC是瞬态的，并且不同脑区域之间的FC的可变性基本上不同。

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