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首页> 外文会议>International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology >Synthesis of Dextran-coated Magnetite Nanoparticles for Cancer Drug Delivery
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Synthesis of Dextran-coated Magnetite Nanoparticles for Cancer Drug Delivery

机译：染色型磁铁矿纳米粒子的合成癌药物递送

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摘要

Drug delivery is the technique of administering a drug to achieve a therapeutic effect in the humans based on the drug safety and efficacy at the targeted therapies. Magnetite nanoparticles (MNPs) can be the controlled drug delivery by using an external magnetic field to lead them into the target tissue. The drugs are attached to the MNPs via the functional groups of coating polymer. Thus, the aim of this research is synthesis of the MNPs by co-precipitation method for cancer drug carriers by using dextran as a biopolymer coating. The cancer drug namely mercaptopurine (Mer) was attached to the MNPs through the functional groups between the dextran and the drug. The synthesized MNPs was the spherical shape with the average sizes between 23-26 nm. However, the particle aggregation was reduced by dextran coating which results in the decrease of the particle size. The synthesized MNPs presented the superparamagnetic behavior with the magnetization in the range of 50-75 emu/g. Thus, dextran coating with optimized molecular weight on MNPs is suitable for cancer drug carriers because they can respond to an external magnetic field.
机译：药物递送是施用药物的技术，以基于针对靶向疗法的药物安全性和功效在人体中达到治疗效果。磁铁矿纳米颗粒（MNP）可以通过使用外部磁场引导它们进入靶组织中的受控药物递送。药物通过涂布聚合物的官能团连接到MNP上。因此，本研究的目的是通过使用葡聚糖作为生物聚合物涂层来合成癌症药物载体的共沉淀方法。癌症药物即巯基嘌呤（MER）通过葡聚糖和药物之间的官能团连接到MNP上。合成的MNP是球形形状，平均尺寸在23-26nm之间。然而，通过葡聚糖涂层减少了颗粒聚集，这导致粒度的降低。合成的MNP在50-75 emu / g的范围内呈现超顺磁性行为。因此，在MNP上具有优化的分子量的葡聚糖涂层适用于癌症药物载体，因为它们可以响应外部磁场。

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