Co-electrospun Scaffolds with Gradients in Fiber Alignment and Chemistry for the Regeneration of Ligament-Bone Transitions

机译：共电纺丝支架，在纤维排列和化学方面具有梯度，可再生韧带-骨过渡。

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This study demonstrates that scaffolds with complex architectures and gradients in chemical properties at physiologically relevant length-scales, can be fabricated by co-electrospinning appropriate polymer solutions from offset spinnerets onto a specially designed collector. The study also indicates that these scaffolds have the potential to be used for the regeneration of graded tissue interfaces such as those present at ligament-bone transitions. Efforts are currently underway to create a gradient of fiber chemistry and mechanical properties by co-electrospinning polymers with significantly different mechanical properties, as well as spatially varying the fiber diameter in the different regions of the scaffolds to further influence cell differentiation.

机译：这项研究表明，可以通过将合适的聚合物溶液从胶印喷丝头共静电纺丝到专门设计的收集器上，来制造具有复杂结构和生理学上相关的化学性质梯度的支架。该研究还表明，这些支架具有用于再生梯度组织界面（如韧带-骨过渡处存在的那些界面）的潜力。当前正在努力通过共电纺丝具有明显不同的机械性能的聚合物，并在空间上改变支架不同区域的纤维直径以进一步影响细胞分化，来创建纤维化学和机械性能的梯度。

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《Society for Biomaterials annual meeting and exposition》|2013年|334|共1页
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Satyavrata Samavedi; Prudhvidhar Gaddam; Abby R Whittington; Aaron S Goldstein;
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1. Gradient fiber electrospinning of layered scaffolds using controlled transitions in fiber diameter [J] . GreyC.P., NewtonS.T., BowlinG.L., Biomaterials . 2013,第21期

机译：使用可控的纤维直径过渡层状支架进行梯度纤维电纺
2. 3D Superelastic Scaffolds Constructed from Flexible Inorganic Nanofibers with Self-Fitting Capability and Tailorable Gradient for Bone Regeneration [J] . Wang Lihuan, Qiu Yuyou, Lv Haijun, Advanced Functional Materials . 2019,第31期

机译：由具有自适应功能和可定制梯度的柔性无机纳米纤维构建的3D超弹性支架，用于骨骼再生。
3. A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration [J] . Khorshidi Sajedeh, Karkhaneh Akbar Journal of tissue engineering and regenerative medicine . 2018,第4期

机译：梯度水凝胶/纤维支架对骨质细胞再生的综述
4. Co-electrospun Scaffolds with Gradients in Fiber Alignment and Chemistry for the Regeneration of Ligament-Bone Transitions [C] . Satyavrata Samavedi, Prudhvidhar Gaddam, Abby R Whittington, Society for Biomaterials annual meeting and exposition . 2013

机译：具有纤维排列梯度和化学的共静电脚手架，韧带骨转换的再生
5. Development of an implantable multilayer three-dimensional scaffold consisting of aligned electrospun fibers for neuronal regeneration applications. [D] . Wang, Han Bing. 2008

机译：开发一种可植入的多层三维支架，该支架由对齐的电纺纤维组成，用于神经元再生应用。
6. Three-Dimensional Printing and Electrospinning Dual-Scale Polycaprolactone Scaffolds with Low-Density and Oriented Fibers to Promote Cell Alignment [O] . Cian Vyas, Gokhan Ates, Enes Aslan, -1

机译：具有低密度和取向纤维的三维印刷和静电纺丝双级聚己内酯支架促进细胞对准
7. Alignment of multiple glial cell populations in 3D nanofiber scaffolds: toward the development of multicellular implantable scaffolds for repair of neural injury [O] . Weightman, Alan P., Jenkins, Stuart I., Pickard, Mark R., 2014

机译：3D纳米纤维支架中多个神经胶质细胞群体的对齐：朝着多细胞植入支架的发展来修复神经损伤
8. Transplantation of Devitalized Muscle Scaffolds is Insufficient for Appreciable De Novo Muscle Fiber Regeneration After Volumetric Muscle Loss Injury. [R] . Garg, K., Ward, C. L., Rathbone, C. R., 2014

机译：失活肌肉支架的移植对于体积肌肉损伤后可感知的De Novo肌纤维再生不足。

Co-electrospun Scaffolds with Gradients in Fiber Alignment and Chemistry for the Regeneration of Ligament-Bone Transitions

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