首页> 外文会议>Society for Biomaterials annual meeting and exposition >NF-κB Decoy Oligodeoxynucleotide Mitigates Polyethylene Wear Particle-Induced Bone Loss but has No Effects on Exogenous Macrophage Infiltration in a Murine Continuous Femoral Particle Infusion Model

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NF-κB Decoy Oligodeoxynucleotide Mitigates Polyethylene Wear Particle-Induced Bone Loss but has No Effects on Exogenous Macrophage Infiltration in a Murine Continuous Femoral Particle Infusion Model

机译：NF-κB诱饵寡脱氧核苷酸减轻聚乙烯磨损颗粒诱导的骨质损失，但对小鼠连续股骨颗粒输注模型中的外源巨噬细胞浸润没有影响

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Conclusions: This in vivo study suggests that NF-κB decoy ODN treatment mitigates wear particle-associated osteolysis using the murine femoral particle infusion model. Decoy ODN treatment increased BMD in femurs exposed to the particles, but had no significant effects on systemic macrophage recruitment. This suggests that the therapeutic effects of decoy ODN are mediated by a reduction of macrophage-associated inflammation and osteoclast activation in the region of particle infusion and drug delivery, rather than systemic macrophage chemotaxis.

机译：结论：在体内研究中，这表明NF-κB诱饵ODN治疗利用鼠股粒子输液模型减轻磨损粒子相关骨质溶解。诱饵ODN治疗将BMD增加到暴露于颗粒的股骨中，但对全身巨噬细胞招募没有显着影响。这表明诱饵ODN的治疗效果是通过在颗粒输注和药物递送区域中的巨噬细胞相关炎症和骨细胞活化的降低来介导的，而不是系统性巨噬细胞趋化性。

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《Society for Biomaterials annual meeting and exposition》|2017年|851 p.|共1页
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Tzu-hua Lin; Akira Nabeshima; Jukka Pajarinen; Luis Cordova; Florence Loi; Emmanuel Gibon; Laura Lu; Karthik Nathan; Zhenyu Yao; Stuart B. Goodman;
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1. Orthopaedic wear particle‐induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF‐κB decoy oligodeoxynucleotide [J] . Lin Tzuhua, Pajarinen Jukka, Nabeshima Akira, Journal of biomedical materials research, Part A . 2017,第11期

机译：通过NF-κB诱饵寡脱氧核苷酸局部输注来减轻矫形磨损粒子诱导的骨质损失和外源巨噬细胞渗透
2. NF-kappa B decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model [J] . Lin Tzu-hua, Pajarinen Jukka, Sato Taishi, Acta biomaterialia . 2016,第Null期

机译：NF-κB诱饵寡聚脱氧核苷酸减轻了小鼠连续输注模型中与磨损颗粒相关的骨丢失
3. NF-kappa B decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model [J] . Lin Tzu-hua, Pajarinen Jukka, Sato Taishi, Acta biomaterialia . 2016,第Null期

机译：NF-Kappa B诱饵寡核苷酸在鼠连续输注模型中减轻耐磨颗粒相关的骨质损失
4. NF-κB Decoy Oligodeoxynucleotide Mitigates Polyethylene Wear Particle-Induced Bone Loss but has No Effects on Exogenous Macrophage Infiltration in a Murine Continuous Femoral Particle Infusion Model [C] . Tzu-hua Lin, Akira Nabeshima, Jukka Pajarinen, Society for Biomaterials annual meeting and exposition . 2017

机译：NF-κB诱饵寡聚寡核苷酸可减轻聚乙烯磨损颗粒引起的骨丢失，但对小鼠连续股骨颗粒输注模型中的外源巨噬细胞浸润没有影响
5. Orthopaedic Wear Particle-induced Bone Loss and Exogenous Macrophage Infiltration is mitigated by Local Infusion of NF-κB Decoy Oligodeoxynucleotide [O] . Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, -1

机译：局部输注NF-κB诱骗性寡脱氧核苷酸可减轻骨科磨损颗粒引起的骨丢失和外源性巨噬细胞浸润
6. NF-kappa B decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model [O] . Lin, Tzu-hua, Pajarinen, Jukka, Sato, Taishi, 2016

机译：NF-κB诱饵寡脱氧核苷酸减轻小鼠连续输注模型中磨损颗粒相关的骨丢失

NF-κB Decoy Oligodeoxynucleotide Mitigates Polyethylene Wear Particle-Induced Bone Loss but has No Effects on Exogenous Macrophage Infiltration in a Murine Continuous Femoral Particle Infusion Model

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