• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Computing in Cardiology Conference >Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion
【24h】

Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion

机译：恢复分散分析预测慢性心力衰竭患者突然心脏死亡

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An increase in the dispersion of action potential duration restitution (APDR) has been associated with higher propensity to suffer from ventricular arrhythmias and sudden cardiac death (SCD). Recently, a marker, Δα, was proposed to non-invasively quantify APDR dispersion from the electrocardiogram (ECG) by computing the ratio between differences in the T-peak-to-T-end (Tpe) and RR intervals at different steady-state conditions. Holter ECG recordings of patients with chronic heart failure divided into two groups, one consisting of victims of SCD and the other of victims of other causes and survivors, were analyzed. ECGs were delineated using a single-lead procedure over the first principal component calculated to emphasize the T-wave. Δα discriminated between the groups formed by SCD and non-SCD victims, respectively, with mean ± SEM values of: Δα = 0.052 ± 0.013 for the former and Δα = 0.026 ± 0.003 for the latter (p < 0.048). In a survival analysis where a threshold on the third quartile of Δα values was set, statistically significantly different event probabilities were obtained in both stratas of the population (p = 0.003). The marker Δα stratifies patients according to their risk of suffering from ventricular arrhythmias that could lead to SCD, with larger restitution dispersion indicating lower survival probability.
机译：在动作电位时程恢复原状（APDR）分散的增加已具有较高的倾向相关的室性心律失常和心脏性猝死（SCD）的困扰。最近，一个标记，Δα，通过计算在T-峰 - T-端（TPE）RR间隔在不同稳态差异和之间的比率提出从心电图（ECG）的非侵入性地进行量化APDR分散状况。患者有慢性心脏衰竭动态心电图记录分为两组，一组由和SCD受害者等的其他原因和幸存者遇难者进行了分析。心电图使用过计算强调T波的第一主成分的单引线过程描绘。 Δα分别由SCD和非SCD受害者，所形成的基团之间区分，用平均值±SEM值：Δα=对于前者0.052±0.013和对于后者（P <0.048）Δα= 0.026±0.003。在上Δα的值的第三个四分位数的阈值设定一个生存分析中，群体（P = 0.003）的两个stratas获得统计学显著不同的事件概率。根据他们的室性心律失常，可能导致猝死，具有较大的恢复分散指示下生存概率痛苦的风险标记Δα进行分层的患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号