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首页> 外文会议>Computing in Cardiology Conference >Non-invasive evaluation of the effect of metoprolol on the atrioventricular node during permanent atrial fibrillation
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Non-invasive evaluation of the effect of metoprolol on the atrioventricular node during permanent atrial fibrillation

机译：永久性评价甲贫酚在永久性心房颤动期间的房室节点效应

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The aim of this study was to evaluate changes in AV nodal properties during administration of metoprolol, using a novel ECG-based method for parameter estimation. The AV nodal parameters account for the probability of an impulse not passing through the fast pathway, the absolute refractory periods of the slow and fast pathways (aRPs and aRPf), representing the functional refractory period, and related prolongation in the respective refractory periods. Twenty patients (age 71 ± 8 years, 14 men) with permanent AF from the RATe control in Atrial Fibrillation (RATAF) database were included in this study. Recordings during baseline and metoprolol administration were analyzed. Furthermore, simulated RR series were generated mimicking metoprolol administration. During metoprolol administration, aRP was significantly prolonged in both pathways (aRPs: 342 ± 39 vs. 408 ± 81 ms, p<;0.001; aRPf: 432 ± 74 vs. 527 ± 83 ms, p<;0.001). Similar results were found for the simulated RR series: both aRPs and aRPf were significantly prolonged with metoprolol. The AV nodal parameters reflect expected changes after metoprolol administration, i.e., a prolongation in functional refractory period. The simulations suggest that aRP may serve as an estimate of the functional refractory period.
机译：本研究的目的是利用基于新的ECG的参数估计来评估氟洛尔洛尔期间的AV节点特性的变化。 AV Nodal参数占不通过快速途径的脉冲的概率，慢速和快速途径（ARPS和ARPF）的绝对耐火周期，代表功能耐火周期，以及各个耐火期间的相关延长。本研究中纳入二十例患者（ratialiaf）数据库中的永久性AF患者（ratial af）的永久性AF患者（71±8岁）。分析了基线和氟洛尔洛尔奖局期间的录音。此外，模拟RR系列是模拟氟托洛尔给药的影响。在甲型托洛尔给药期间，ARP在途径（ARPS：342±39和408±81ms，P <; 0.001; ARPF：432±74与527±83ms，P <; 0.001）中。对模拟的RR系列发现类似的结果：ARP和ARPF两者和ARPF都与甲金属托洛尔显着延长。 AV Nodal参数反映了美容抑制剂给药后的预期变化，即功能耐火期的延长。模拟表明ARP可以作为功能耐火期的估计。

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