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Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose

机译：肿瘤肿瘤和支持血管系统生长动力学的双隔室建模优化目的

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We introduce a nonlinear bi-compartmental dynamic tumor cell and supporting vasculature volume growth model which takes into account nutrient and cell proliferation, necrosis and angiogenesis. Validation of the model requires measurement data on tumor volume during the therapy; for explicit identification of vasculature growth dynamic, in vivo measurement data on vasculature volume during the therapy are required as well. We show that the model can be used for the evaluation of drug dosage protocols.

机译：我们介绍了非线性双隔层动态肿瘤细胞和支持血管系统体积生长模型，其考虑了营养和细胞增殖，坏死和血管生成。验证模型需要在治疗过程中对肿瘤体积进行测量数据;为了明确识别脉管系统生长动态，还需要在脉管系统的体内测量数据中，也是如此。我们表明该模型可用于评估药物剂量方案。

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《IEEE Annual Conference on Decision and Control》|2017年|4187-5043p|共5页
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David Csercsik; Johanna Sapi; Tamas Gonczy; Levente Kovacs;
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1. Modeling Tumor Growth and Treatment Resistance Dynamics Characterizes Different Response to Gefitinib or Chemotherapy in Non‐Small Cell Lung Cancer [J] . Mario Nagase, Sergey Aksenov, Hong Yan, CPT: Pharmacometrics & Systems Pharmacology . 2020,第3期

机译：肿瘤生长和治疗抗性动态的造型表征对非小细胞肺癌的吉替尼或化疗的不同反应
2. Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model [J] . Jonathan P. Celli, Imran Rizvi, Conor L. Evans, Journal of biomedical optics . 2010,第5期

机译：定量成像揭示了三维卵巢癌模型中的异质生长动力学和依赖治疗的残余肿瘤分布
3. An approach for vascular tumor growth based on a hybrid embedded/homogenized treatment of the vasculature within a multiphase porous medium model [J] . Kremheller Johannes, Vuong Anh-Tu, Schrefler Bernhard A., International journal for numerical methods in biomedical engineering . 2019,第11期

机译：基于多相多孔介质模型内血管的混合嵌入式/均质化处理的血管肿瘤生长方法
4. Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose [C] . Dávid Csercsik, Johanna Sápi, Tamás Gönczy, IEEE Annual Conference on Decision and Control . 2017

机译：肿瘤双室建模和支持的脉管系统生长动力学，以优化癌症治疗
5. Integral-Spectral Methods: Fundamental Principles and Selected Applications to Healthcare (Cancerous Tumor Treatment, Dialysis, and Electrokinetic Hydrodynamics in Kidney Treatment) and Related Pedagogical Aspects [D] . ?Allred, Ashley Nastasia 2020

机译：积分光谱方法：基本原则和选定的医疗保健申请（肾治疗中癌症治疗，透析和电动流体动力学）和相关的教学方面
6. Modeling Tumor Growth and Treatment Resistance Dynamics Characterizes Different Response to Gefitinib or Chemotherapy in Non‐Small Cell Lung Cancer [O] . Mario Nagase, Sergey Aksenov, Hong Yan, 2020

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7. Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose [O] . David Csercsik, Johanna Sapi, Tamas Gonczy, 2017

机译：肿瘤肿瘤和支持血管系统生长动力学的双隔室建模优化目的
8. Treatment of Mestastatic Breast Cancer by Photodynamic Therapy Induced Anti-Tumor Immunity in a Murine Model [R] . Castano, A. P. 2005

机译：光动力疗法诱导小鼠乳腺癌在小鼠模型中的抗肿瘤免疫治疗

Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose

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