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首页> 外文会议>Conference on reflection, scattering, and diffraction from surfaces >Cone beam X-ray luminescence computed tomography reconstruction with a priori anatomical information
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Cone beam X-ray luminescence computed tomography reconstruction with a priori anatomical information

机译：具有先验解剖学信息的锥形束X射线荧光计算机断层摄影术重建

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摘要

X-ray luminescence computed tomography (XLCT) is a novel molecular imaging modality that reconstructs the optical distribution of x-ray-excited phosphor particles with prior information of anatomical CT image. The prior information improves the accuracy of image reconstruction. The system can also present anatomical CT image. The optical system based on a highly sensitive charge coupled device (CCD) is perpendicular to a CT system. In the XLCT system, the x-ray was adopted to excite the phosphor of the sample and CCD camera was utilized to acquire luminescence emitted from the sample in 360-degree projections in free-space. In this study, the fluorescence diffuse optical tomography (FDOT)-like algorithm was used for image reconstruction, the structural prior information was incorporated in the reconstruction by adding a penalty term to the minimization function. The phosphor used in this study is Gd_2O_2S:Tb. For the simulation and experiments, the data was collected from 16 projections. The cylinder phantom was 40 mm in diameter and contains 8 mm diameter inclusion; the phosphor in the in vivo study was 5 mm in diameter at a depth of 3 mm. Both the estimation errors were no more than 5%. Based on the results from these simulation and experimental studies, the novel XLCT method has demonstrated the feasibility for in vivo animal studies.
机译：X射线计算机断层扫描（XLCT）是一种新颖的分子成像方法，可利用解剖CT图像的先验信息重建X射线激发的荧光粉颗粒的光学分布。先验信息提高了图像重建的准确性。该系统还可以呈现解剖CT图像。基于高灵敏度电荷耦合器件（CCD）的光学系统垂直于CT系统。在XLCT系统中，采用X射线激发样品的磷光体，并使用CCD摄像机获取在自由空间中以360度投影的方式从样品发出的发光。在这项研究中，像荧光扩散光学层析成像（FDOT）一样的算法用于图像重建，通过在最小化函数中增加惩罚项，将结构先验信息纳入重建中。本研究中使用的荧光粉是Gd_2O_2S：Tb。为了进行仿真和实验，从16个投影中收集了数据。圆柱体模型的直径为40毫米，包含8毫米直径的夹杂物。体内研究中的荧光粉直径为5毫米，深度为3毫米。两种估计误差均不超过5％。基于这些模拟和实验研究的结果，新颖的XLCT方法证明了体内动物研究的可行性。

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