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首页> 外文会议>International symposium on bioinformatics research and applications >LncRNA2Function: A Comprehensive Resource for Functional Investigation of Human lncRNAs Based on RNA-seq Data
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LncRNA2Function: A Comprehensive Resource for Functional Investigation of Human lncRNAs Based on RNA-seq Data

机译：LncRNA2Function：基于RNA序列数据的人类lncRNA功能研究的综合资源

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The GENCODE project has collected over 10,000 human long non-coding RNA (lncRNA) genes. However, the vast majority of them remain to be functionally characterized. Computational investigation of potential functions of human lncRNA genes is helpful to guide further experimental studies on lncRNAs. In this study, based on expression correlation between lncRNAs and protein-coding genes across 19 human normal tissues, we used the hypergeometric test to functionally annotate a single lncRNA or a set of lncRNAs with significantly enriched functional terms among the protein-coding genes that are co-expressed with the lncRNA(s). The functional terms include all nodes in the Gene Ontology (GO) and 4,380 human biological pathways collected from 12 pathway databases. We mapped 9,625 human lncRNA genes to GO terms and biological pathways. Finally, we developed the first ontology-driven tool named lncRNA2Function, which enables researchers to browse the lncRNAs associated with a specific functional term, the functional terms associated with a specific lncRNA, or to assign functional terms to a set of human lncRNA genes such as a cluster of co-expressed lncRNAs.
机译：GENCODE项目已收集了10,000多个人类长非编码RNA（lncRNA）基因。但是，它们中的绝大多数仍需进行功能表征。人类lncRNA基因潜在功能的计算研究有助于指导lncRNA的进一步实验研究。在这项研究中，基于19个人类正常组织中lncRNA与蛋白质编码基因之间的表达相关性，我们使用超几何学测试功能注释了单个lncRNA或一组lncRNA，其中蛋白质编码基因中的lncRNA具有明显丰富的功能术语。与lncRNA共表达。功能术语包括基因本体论（GO）中的所有节点以及从12条途径数据库中收集的4,380条人类生物途径。我们将9,625个人类lncRNA基因定位到GO术语和生物学途径。最后，我们开发了第一个由本体驱动的工具，名为lncRNA2Function，这使研究人员能够浏览与特定功能术语相关的lncRNA，与特定lncRNA相关的功能术语，或将功能术语分配给一组人类lncRNA基因，例如共表达的lncRNA簇。

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