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首页> 外文会议>Annual NSTI nanotechnology conference and expo;TechConnect world innovation conference expo >Nanodrug delivery by single-walled carbon nanotubes (SWCNTs) in the central nervous system induces neurotoxicity. Potential neuroprotective effects of Cerebrolysin
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Nanodrug delivery by single-walled carbon nanotubes (SWCNTs) in the central nervous system induces neurotoxicity. Potential neuroprotective effects of Cerebrolysin

机译：在中枢神经系统中通过单壁碳纳米管（SWCNT）进行纳米药物递送会引起神经毒性。脑溶素的潜在神经保护作用

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摘要

Our military personnel are often inflicted with brain or spinal cord injury during combat operations caused by gunshot, missile explosions, fall or direct blunt or sharp trauma to their CNS leading to life threatening illnesses. Recently, single-walled carbon nanotubes (SWCNTs) are used for nano drug delivery in cancer therapy however; SWCNTs induced neurotoxicity is not well known. In this innovation, we used Cerebrolsyin, a balanced composition of several neurotrophic factors and active peptide fragments in attenuating SWCNTs induced neurotoxicity in the rat central nervous system (CNS). These observations support the idea that co-administration of Cerebrolsyin with SWCNTs is needed to enhance the neuroprotective effects of nanodrug delivery using SWCNTs as a vehicle.
机译：在战斗行动中，我们的军事人员经常因枪弹，导弹爆炸，坠落或对CNS的直接钝击或强烈伤害而导致大脑或脊髓受伤，从而导致生命危险。最近，单壁碳纳米管（SWCNTs）被用于癌症治疗中的纳米药物递送。 SWCNTs诱导的神经毒性尚不为人所知。在这项创新中，我们使用脑啡肽酶（一种由几种神经营养因子和活性肽片段组成的平衡成分）来减弱SWCNTs诱导的大鼠中枢神经系统（CNS）的神经毒性。这些观察结果支持需要将脑啡肽与SWCNT共同给药以增强使用SWCNT作为载体的纳米药物递送的神经保护作用的想法。

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