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Dispersion of Single-Walled Carbon Nanotubes (SWCNTs) in Aqueous Solution and Reversion of SWCNT Aggregates.

机译：单壁碳纳米管（SWCNT）在水溶液中的分散和SWCNT聚集体的还原。

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摘要

Due to their unique physical properties, single-walled carbon nanotubes (SWCNTs) have become increasingly important in applications as diverse as biosensors and building blocks for nano-electronics. SWCNTs are considered to be effective drug and gene carriers because they have the ability to either directly penetrate or be endocytosed into cells with relatively low or no toxicity. However, there is a limitation: in order to be used as drug or gene carriers, SWCNTs must be dispersed in aqueous solution. In fact, studies have shown that an aggregated form of SWCNTs induces a toxic response in vivo, thus limiting their use as delivery tools. This toxic response, consisting of aggregate accumulation in the lung and spleen and consequent inflammation and fibrosis, motivated us to study strategies for achieving effective SWCNT dispersion in aqueous solution. We investigated the mechanisms of SWCNT dispersion and aggregation and how certain SWCNT aggregates can be re-dispersed by addition of chelating or reducing agents. We also developed a method to re-disperse SWCNT aggregates by using enzymes, which has the potential to control the aggregation status of SWCNTs in solution. Our studies and findings can advance the development of SWCNTs for future applications in drug/DNA delivery.
机译：由于其独特的物理特性，单壁碳纳米管（SWCNT）在生物传感器和纳米电子学构建模块等各种应用中变得越来越重要。 SWCNT被认为是有效的药物和基因载体，因为它们能够直接穿透或被内吞进入毒性相对较低或无毒性的细胞中。但是，存在一个局限性：为了用作药物或基因载体，SWCNT必须分散在水溶液中。实际上，研究表明，SWCNT的聚集形式在体内会引起毒性反应，从而限制了它们作为递送工具的用途。这种毒性反应包括肺和脾脏中的聚集物积累以及随之而来的炎症和纤维化，促使我们研究在水溶液中实现有效SWCNT分散的策略。我们研究了SWCNT分散和聚集的机制，以及某些SWCNT聚集体如何通过添加螯合剂或还原剂而重新分散。我们还开发了一种通过使用酶重新分散SWCNT聚集体的方法，该方法具有控制溶液中SWCNT聚集状态的潜力。我们的研究和发现可以促进SWCNTs的开发，以便在药物/ DNA输送中的未来应用。

著录项

  • 作者

    Koh, Byumseok Eric.;

  • 作者单位

    University of Michigan.;

  • 授予单位 University of Michigan.;
  • 学科 Health Sciences Pharmacy.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 177 p.
  • 总页数 177
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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