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首页> 外文会议>Annual conference of the International Society of Exposure Science >Prenatal, but not Postnatal, Exposure to Polychlorinated Biphenyls (PCBs) is associated with ADHD-Related Behaviors its 8-Year-Old Children
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Prenatal, but not Postnatal, Exposure to Polychlorinated Biphenyls (PCBs) is associated with ADHD-Related Behaviors its 8-Year-Old Children

机译：产前（而非产后）接触多氯联苯（PCB）与8岁儿童的ADHD相关行为有关

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Background: The neurotoxicity of prenatal PCB exposure has been established in both animal and human studies. Conversely, few human studies have replicated the behavioral effects of postnatal exposures that have been observed in monkeys, possibly because of challenges to postnatal exposure estimation. To refine exposure assessment, we previously developed and validated a pharmacokinetic model to estimate children's PCB-153 levels across development. Aims: To assess whether postnatal exposure to PCBs, estimated using a pharmacokinetic model, is associated with ADHD-related behaviors in 8-year-olds enrolled in a birth cohort study of prenatal contaminant exposure and subsequent child development. Methods: We used a published pharmacokinetic model to estimate monthly PCB-153 levels in children through 12 months of age based on parameters such as breastfeeding, cord serum PCB-153 levels and growth. Behavior was evaluated using the Conner's Rating Scales for teachers (CRS-T). The associations between PCB-153 levels and 4 CRS-T indices were assessed using multivariable quantile regression at the 50th and 75th percentiles, where higher percentiles reflect worse behavior. Results: Cord serum PCB-153 levels (median: 39 ng/g lipids, 5th-95th percentile: 7-317) were associated with ADHD-related behaviors, although statistical significance was only observed with quantile regression models at the 75th percentile. This association decreased in strength with later postnatal levels. For example, the 1.5 point (95 % CI: 0.3, 2.1) increase in Conner's ADHD index score associated with an inter-quartile range change in cord serum PCB-153 levels weakened to 0.9 (95 % CI: 0.1, 3.0) and 0.1 (95 % CI:-0.3, 2) for estimated children's levels at 2 and 12 months, respectively. Conclusions: Results suggest that the association between PCBs and behavior in 8-year-olds is mainly attributable to prenatal exposure and is more evident in children with worse behavioral scores.
机译：背景：在动物和人体研究中均已确定了产前PCB暴露的神经毒性。相反，很少有人类研究能够复制猴子中观察到的产后暴露的行为影响，这可能是由于产后暴露估算面临的挑战。为了完善暴露评估，我们之前开发并验证了药代动力学模型，以评估整个开发过程中儿童的PCB-153水平。目的：为了评估使用药代动力学模型估算的出生后PCBs暴露与8岁年龄组与ADHD相关的行为是否相关，该研究参加了出生前污染物暴露和随后的儿童发育的队列研究。方法：我们使用已发布的药代动力学模型，根据诸如母乳喂养，脐带血清PCB-153水平和生长等参数，估算了12个月大的儿童每月的PCB-153水平。使用康纳教师评定量表（CRS-T）对行为进行评估。 PCB 153水平与4个CRS-T指数之间的关联在第50和75个百分位数处使用多变量分位数回归进行了评估，其中较高的百分位数反映了较差的行为。结果：脐带血清PCB-153水平（中位数：39 ng / g脂质，第5-95个百分位数：7-317）与ADHD相关行为有关，尽管仅在第75个百分位数的分位数回归模型中观察到了统计学意义。这种关联的强度随着后来的出生后水平而降低。例如，与脐带血清PCB-153水平四分位间变化相关的Conner ADHD指数得分提高1.5点（95％CI：0.1、3.0）和0.1 （95％CI：-0.3，2）分别估计儿童在2个月和12个月时的水平。结论：结果表明，8岁儿童的多氯联苯与行为之间的关联主要归因于产前暴露，并且在行为评分较差的儿童中更为明显。

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