• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Annual conference of the International Society of Exposure Science >Risks from chemical and non-chemical stressors associated with attention deficit hyperactivity disorder {ADHD)-like behavior using structural equation models
【24h】

Risks from chemical and non-chemical stressors associated with attention deficit hyperactivity disorder {ADHD)-like behavior using structural equation models

机译：使用结构方程模型的与注意缺陷多动障碍（ADHD）样行为相关的化学和非化学应激源的风险

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. ADHD-like behavior - assessed using psychometric tests and behavioral rating scales - is associated with multiple chemical and non-chemical stressors, including sociodemographic characteristics and exposure to heavy metals and organochlorines. However, the effect of combined exposures has not been evaluated. Aim. To determine the interactions between a priori risk factors of ADHD-like behavior using structural equation modeling (SEM), in a framework which informs cumulative risk assessment. Methods. Using data from an established birth cohort in the low-income urban community of New Bedford, Massachusetts, we developed models predicting exposures to risk factors associated with ADHD-like behaviors, using individual level data from the cohort and geospatial and demographic information from public databases. Models were built for postnatal chemical exposure (e.g. lead (Pb)), prenatal chemical exposures (e.g., Pb, organochlorines (PCBs, DDE), and mercury (Hg)) and non-chemical exposures (e.g., stress). ADHD-like behavior was evaluated using the Connors' Teacher rating scales, and SEMs were applied to model the relationship between predictors of exposure, exposures, and ADHD-like behavior. Results. Common predictors of prenatal biomarker measures of Pb, PCB, DDE and Hg included mother's date of birth, country of birth, and household income. Food consumption patterns (e.g. fish and organ meat) were associated with prenatal exposure to DDE, PCB and Hg, while home attributes (e.g. construction year and assessed value) were associated with postnatal blood Pb concentrations. SEMs illustrated that sociodemographic characteristics both acted as predictors of exposures and had direct associations with ADHD-like behavior. Conclusions. We developed a structural equation model of environmental risk factors for ADHD-like behavior which integrates chemical and non-chemical stressors. The model will inform a community wide cumulative risk assessment model.
机译：背景。使用心理测验和行为评级量表评估的类ADHD行为与多种化学和非化学应激源相关，包括社会人口统计学特征以及暴露于重金属和有机氯中。但是，尚未评估综合暴露的影响。目的。为了确定结构复杂的先验风险因素之间的相互作用，采用结构方程模型（SEM），该方法可为累积风险评估提供依据。方法。利用来自马萨诸塞州新贝德福德的低收入城市社区已建立的出生队列的数据，我们使用队列中的个人数据以及公共数据库中的地理空间和人口统计学信息，开发了预测与多动症样行为相关的危险因素的模型。建立了针对产后化学暴露（例如铅（Pb）），产前化学暴露（例如Pb，有机氯（PCBs，DDE）和汞（Hg））和非化学暴露（例如压力）的模型。使用Connors教师评分量表评估类ADHD行为，并使用SEM来模拟暴露，暴露和类ADHD行为的预测因子之间的关系。结果。铅，多氯联苯，DDE和汞的产前生物标志物指标的常见预测指标包括母亲的出生日期，出生国家和家庭收入。食物的消费方式（例如鱼和内脏肉）与产前DDE，PCB和Hg的暴露有关，而家庭属性（例如建筑年限和评估值）与产后血中Pb的浓度有关。扫描电镜表明，社会人口统计学特征既可以作为暴露的预测指标，又可以与多动症样行为直接相关。结论我们开发了一种结构风险模型的ADHD行为的环境风险因素的结构方程模型，该模型整合了化学和非化学应激源。该模型将为社区范围的累积风险评估模型提供参考。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号