• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Annual conference of the International Society of Exposure Science >Estimating and Evaluating the Total Exposure of German Children to Di(2-ethylhexyl) phthalate (DEHP) and Di-isononyl phthalate (DINP)
【24h】

Estimating and Evaluating the Total Exposure of German Children to Di(2-ethylhexyl) phthalate (DEHP) and Di-isononyl phthalate (DINP)

机译：估计和评估德国儿童对邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸二异壬酯（DINP）的总暴露量

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Being associated with adverse health effects, the human exposure to DEHP and DiNP is subject of concern. For adults, food is the main source of exposure. However, for children, additional sources of DEHP exposure must be taken into account. Methods: Our exposure modelling study comprised a review of data on DEHP and DINP in food, consumer products, and house dust. This includes published data as well as current measurements of DEHP and DINP in consumer goods (concentration and migration) and selected foods. Non-intended contact with consumer products via "mouthing" is of particular importance. Mouthing times used in this project have been derived from a joint evaluation of studies coming from the literature. The exposure via all pathways was estimated using deterministic and probabilistic approaches. Results: Diet contributes most to the total exposure, followed by mouthing and house dust intake. Mouthing is estimated to cause an exposure to DEHP of 0.9 (P50) /10.8 (P95) and 3.9 μg/(kgbw d) using probabilistic and deterministic calculations, respectively. Calculations for DINP lead to comparable estimates. The exposure to DEHP via house dust is estimated to be 2.3 (P50) / 4.7 (P95) by the probabilistic model and 1.4 - 6.8 μg/(kgbw d) when applying deterministic calculations. The exposure to DINP via house dust is estimated to be approx. 25 % lower than for DEHP. Conclusions: On average German children are exposed to DEHP/DINP below the current TDI. For a small fraction of the population, however, TDI exceedance cannot be excluded due to unfavourable exposure conditions. Mouthing can be assumed to contribute significantly to children's total exposure. Different uncertainties exist for the respective sources and paths of exposure. Current data on DEHP and DINP in non-regulated consumer products are scarce, which warrants further monitoring. Funding by the Federal Minister for the Environment, Nature Conservation and Nuclear Safety is gratefully acknowledged.
机译：背景：与不良健康影响相关，人体暴露于DEHP和DiNP受到关注。对于成年人来说，食物是暴露的主要来源。但是，对于儿童，必须考虑DEHP暴露的其他来源。方法：我们的暴露建模研究包括对食品，消费品和房屋尘埃中的DEHP和DINP数据的审查。其中包括已发布的数据以及消费品（浓度和迁移）和精选食品中DEHP和DINP的当前测量值。通过“嘴巴”非预期地与消费品接触特别重要。该项目中使用的口述时间是根据对文献研究的联合评估得出的。使用确定性和概率方法估算了所有途径的暴露量。结果：饮食对总暴露量的影响最大，其次是漱口和摄入室内灰尘。据估计，使用概率计算和确定性计算，口入分别导致0.9（P50）/10.8（P95）和3.9μg/（kgbw d）的DEHP暴露。 DINP的计算得出可比的估计。根据概率模型，通过室内灰尘暴露于DEHP的暴露估计为2.3（P50）/ 4.7（P95），而应用确定性计算时，估计为1.4-6.8μg/（kgbw d）。据估计，通过室内灰尘暴露在DINP中的暴露量约为50％。比DEHP低25％。结论：平均而言，德国儿童的DEHP / DINP低于当前的TDI。然而，由于不利的接触条件，对于一小部分人口，无法排除TDI超标。可以说嘴巴对儿童的总暴露量有很大的影响。对于各自的暴露源和暴露途径，存在不同的不确定性。目前缺乏关于非管制消费品中DEHP和DINP的数据，因此有必要进行进一步监测。非常感谢联邦环境，自然保护和核安全部长的资助。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号