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首页> 外文会议>Annual conference of the International Society of Exposure Science >Urinary metabolites of the UV filter Ethylhexyl Salicylate to be used as biomarkers of exposure in human biomonitoring
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Urinary metabolites of the UV filter Ethylhexyl Salicylate to be used as biomarkers of exposure in human biomonitoring

机译：紫外线滤光剂的尿代谢物乙基己基水杨酸酯用作人生物监唱体暴露的生物标志物

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Accident Insurance (IPA), Bochum, Germany Holger Martin Koch, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany 2-Ethylhexyl salicylate (syn. EHS, octyl salicylate, octisalate) is a UV filter substance used in one third of sun screen formulations and in other personal care products in concentrations up to 5% (maximum authorized concentration within the USA and the EC)[1,2]. Fish model experiments indicated endocrine disrupting activity of EHS [3]. Because of the likely exposure of the general population, EHS was selected as a substance of interest by the cooperation project between the German Federal Ministry for Environment (BMUB) and the German Chemical Industry Association (VCI), which has the aim to provide biomarker based exposure data for fifty emerging substances of concern. In a human metabolism study (one male volunteer) three alkyl chain oxidized EHS metabolites (hydroxy EHS, oxo EHS, and EHS carboxylic acid) were tentatively identified as possible biomarkers of exposure. After custom synthesis of analytical standards (unlabeled and stable isotope labeled) and development of an analytical method post dose urine samples (5 mg EHS) of three male volunteers were analyzed. We report the elimination kinetics for these EHS metabolites. The results also allowed the calculation of urinary conversion factors. In further studies the occurrence of the identified EHS metabolites in samples from the general population and their suitability as biomarkers of exposure will be investigated. The study has been approved by the ethical review board of the Ruhr-University Bochum (Reg. No.: 4288-12).
机译：意外保险（IPA），Bochum，德国Holger Martin Koch，德国社会事故保险（IPA），Boochum，德国2-乙基己基水杨酸盐​​（SYN。EHS，SALICYLATE，OCTITITALATE）是UV过滤器在Sun筛剂配方中的三分之一和其他个人护理产品中使用的物质，浓度高达5％（美国和EC的最大授权集中）[1,2]。鱼模型实验表明EHS的内分泌破坏活性[3]。由于普通人口的可能暴露，EHS被选为德国联邦环境（BMUB）与德国化学工业协会（VCI）之间的合作项目的一个感兴趣的物质，这一目标是提供基于生物标志物的旨在提供生物标志物关注的五十个新出现物质的暴露数据。在人类代谢研究（一个雄性志愿者）中，三个烷基链氧化EHS代谢物（羟基EHS，OXO EHS和EHS羧酸）被暂时鉴定为可能的暴露生物标志物。分析了分析标准的定制合成（标记的未标记和稳定同位素）并分析了三个雄性志愿者的分析方法后剂量尿液样本（5mg EHS）。我们报告了这些EHS代谢物的消除动力学。结果还允许计算泌尿源转换因子。在进一步的研究中，将研究来自一般人群的样品中所鉴定的EHS代谢物及其作为暴露生物标志物的适用性。该研究已被Ruhr-University Bochum的道德审查委员会批准（REG。No.:2288-12）。

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