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首页> 外文会议>Annual conference of the International Society of Exposure Science >Urinary metabolites of the UV filter Ethylhexyl Salicylate to be used as biomarkers of exposure in human biomonitoring
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Urinary metabolites of the UV filter Ethylhexyl Salicylate to be used as biomarkers of exposure in human biomonitoring

机译：紫外线过滤器水杨酸乙基己酯的尿液代谢物，用作人体生物监测中的暴露生物标志物

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Accident Insurance (IPA), Bochum, Germany Holger Martin Koch, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany 2-Ethylhexyl salicylate (syn. EHS, octyl salicylate, octisalate) is a UV filter substance used in one third of sun screen formulations and in other personal care products in concentrations up to 5% (maximum authorized concentration within the USA and the EC)[1,2]. Fish model experiments indicated endocrine disrupting activity of EHS [3]. Because of the likely exposure of the general population, EHS was selected as a substance of interest by the cooperation project between the German Federal Ministry for Environment (BMUB) and the German Chemical Industry Association (VCI), which has the aim to provide biomarker based exposure data for fifty emerging substances of concern. In a human metabolism study (one male volunteer) three alkyl chain oxidized EHS metabolites (hydroxy EHS, oxo EHS, and EHS carboxylic acid) were tentatively identified as possible biomarkers of exposure. After custom synthesis of analytical standards (unlabeled and stable isotope labeled) and development of an analytical method post dose urine samples (5 mg EHS) of three male volunteers were analyzed. We report the elimination kinetics for these EHS metabolites. The results also allowed the calculation of urinary conversion factors. In further studies the occurrence of the identified EHS metabolites in samples from the general population and their suitability as biomarkers of exposure will be investigated. The study has been approved by the ethical review board of the Ruhr-University Bochum (Reg. No.: 4288-12).
机译：德国波鸿事故保险（IPA）霍尔格·马丁·科赫（Holger Martin Koch），德国波鸿德国预防和职业医学研究所，德国波鸿2-乙基己基水杨酸酯（合成EHS，辛基水杨酸酯，辛基磺酸酯）是一种紫外线过滤器用于防晒霜配方和其他个人护理产品中的三分之一的物质，其浓度最高为5％（美国和欧共体内部的最大授权浓度）[1,2]。鱼模型实验表明EHS的内分泌干扰活性[3]。由于普通人群可能接触毒品，德国联邦环境部（BMUB）和德国化学工业协会（VCI）之间的合作项目选择EHS作为关注的物质，其目的是提供基于生物标志物的五十种令人关注的新兴物质的暴露数据。在一项人体代谢研究（一名男性志愿者）中，初步确定了三种烷基链氧化的EHS代谢物（羟基EHS，氧代EHS和EHS羧酸）可能是暴露的生物标志物。在定制合成分析标准品（未标记和稳定同位素标记的）并开发了一种分析方法后，对三名男性志愿者的剂量后尿液样本（5 mg EHS）进行了分析。我们报告了这些EHS代谢产物的消除动力学。结果还可以计算尿液转化因子。在进一步的研究中，将调查一般人群样本中已鉴定出的EHS代谢物的发生及其作为暴露生物标志物的适用性。这项研究已获得波鸿鲁尔大学伦理审查委员会的批准（注册号：4288-12）。

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