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首页> 外文会议>Annual conference of the International Society of Exposure Science >Racial/ethnic differences in prenatal dietary intake of antioxidants and methyl-donors: Implications for environmental health risk
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Racial/ethnic differences in prenatal dietary intake of antioxidants and methyl-donors: Implications for environmental health risk

机译：产前膳食摄入抗氧化剂和甲基供体的种族/民族差异：对环境健康风险的影响

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Background: Oxidative stress and epigenetic changes are key mechanisms for environmental exposures, including ambient air pollution. Antioxidants and methyl-donors may modulate toxic effects. Aim: We examined correlates of total dietary intakes of antioxidants and methyl-donors in an urban, ethnically mixed prenatal cohort (n=275) designed to study the effects of traffic-related air pollution, social stress, and dietary factors on prenatal programming of autonomic function. Methods: Total daily antioxidant and methyl-donor intakes were calculated from a food frequency questionnaire. Estimated Average Requirements indexed antioxidant/methyl-donor inadequacy (≥2 micronutrient inadequacies per group). Stress was indexed by negative life events. We examined differences in dietary intakes based on race and stress levels. Race-stratified logistic regression was used to examine effects of social stress on antioxidant and methyl-donor inadequacy adjusting for maternal education and body mass index. Results: Women were largely minority (43% Hispanic, 18% black, and 8% mixed). Vitamins E, folate, B6, and trace minerals zinc, magnesium, and iron were the most prevalent inadequacies. Differing antioxidant and methyl-donor intakes were observed by race, with blacks and Hispanics consistently having lower intakes than their counterparts (p＜0.01). Higher stress was associated with antioxidant and methyl-donor inadequacy, particularly among blacks [odds of antioxidant (aOR: 2.09, 95% CI 1.15-3.80) and methyl-donor (aOR: 2.22, 95% CI 1.16-4.25) inadequacy]. Conclusions: Observed racial differences in dietary intakes of antioxidants/methyl-donors may, in part, explain differences in vulnerability to environmental toxicants (e.g., traffic pollution) and consequent health disparities. Next steps will include assessing modifying effects of dietary inadequacies on the role of traffic pollution-related fetal programming across racial groups.
机译：背景：氧化应激和表观遗传变化是环境暴露的关键机制，包括环境空气污染。抗氧化剂和甲基供体可以调节毒性作用。目的：我们检查了抗氧化剂和甲基供体中的膳食摄入量的相关性，旨在研究流量相关的空气污染，社会压力和膳食因素对产前编程的影响自主功能。方法：从食物频率调查问卷计算每日总抗氧化剂和甲基供体摄入量。估计平均需求指数化抗氧化剂/甲基供体不足（≥2每组微量营养素不足）。压力被负面生活事件索引。我们研究了基于种族和压力水平的膳食摄入量的差异。种族分层后勤回归用于检查社会压力对抗氧化剂和甲基供体不足调整妇幼教育和体重指数的影响。结果：女性主要是少数群体（43％西班牙裔，18％黑，8％的混合）。维生素E，叶酸，B6和痕量矿物锌，镁和铁是最普遍的不足。通过种族观察不同的抗氧化剂和甲基供体摄入量，黑人和西班牙裔始终如一的摄入量比其对应物（P <0.01）。较高的应力与抗氧化剂和甲基供体不足，特别是黑人（AOR：2.09,95％CI 1.15-3.80）和甲基供体（AOR：2.22,95％CI 1.16-4.25）的不足]。结论：观察抗氧化剂/甲基供体的膳食摄入量的种族差，部分地解释了对环境毒物（例如，交通污染）和随后的卫生差异的脆弱性差异。下一步将包括评估饮食不足对种族群体交通污染相关胎儿规划作用的修改效果。

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