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首页> 外文会议>Annual conference of the International Society of Exposure Science >Racial/ethnic differences in prenatal dietary intake of antioxidants and methyl-donors: Implications for environmental health risk
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Racial/ethnic differences in prenatal dietary intake of antioxidants and methyl-donors: Implications for environmental health risk

机译：产前饮食中抗氧化剂和甲基供体的种族/种族差异：对环境健康风险的影响

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Background: Oxidative stress and epigenetic changes are key mechanisms for environmental exposures, including ambient air pollution. Antioxidants and methyl-donors may modulate toxic effects. Aim: We examined correlates of total dietary intakes of antioxidants and methyl-donors in an urban, ethnically mixed prenatal cohort (n=275) designed to study the effects of traffic-related air pollution, social stress, and dietary factors on prenatal programming of autonomic function. Methods: Total daily antioxidant and methyl-donor intakes were calculated from a food frequency questionnaire. Estimated Average Requirements indexed antioxidant/methyl-donor inadequacy (≥2 micronutrient inadequacies per group). Stress was indexed by negative life events. We examined differences in dietary intakes based on race and stress levels. Race-stratified logistic regression was used to examine effects of social stress on antioxidant and methyl-donor inadequacy adjusting for maternal education and body mass index. Results: Women were largely minority (43% Hispanic, 18% black, and 8% mixed). Vitamins E, folate, B6, and trace minerals zinc, magnesium, and iron were the most prevalent inadequacies. Differing antioxidant and methyl-donor intakes were observed by race, with blacks and Hispanics consistently having lower intakes than their counterparts (p＜0.01). Higher stress was associated with antioxidant and methyl-donor inadequacy, particularly among blacks [odds of antioxidant (aOR: 2.09, 95% CI 1.15-3.80) and methyl-donor (aOR: 2.22, 95% CI 1.16-4.25) inadequacy]. Conclusions: Observed racial differences in dietary intakes of antioxidants/methyl-donors may, in part, explain differences in vulnerability to environmental toxicants (e.g., traffic pollution) and consequent health disparities. Next steps will include assessing modifying effects of dietary inadequacies on the role of traffic pollution-related fetal programming across racial groups.
机译：背景：氧化应激和表观遗传变化是环境暴露（包括周围空气污染）的关键机制。抗氧化剂和甲基供体可能会调节毒性作用。目的：我们研究了城市，种族混合的产前队列（n = 275）中饮食中抗氧化剂和甲基供体的总摄入量的相关性，目的是研究与交通有关的空气污染，社会压力和饮食因素对孕妇的产前程序设计的影响。自主功能。方法：从食物频率调查表计算每日总抗氧化剂和甲基供体摄入量。估计的平均需求量表明抗氧化剂/甲基供体不足（每组≥2种微量营养素不足）。负面生活事件指示了压力。我们根据种族和压力水平检查了饮食摄入量的差异。种族分层逻辑回归用于检验社会压力对抗氧化剂和甲基供体不足的影响，以调整孕产妇教育和体重指数。结果：女性大部分为少数民族（43％的西班牙裔，18％的黑人和8％的混血儿）。维生素E，叶酸，B6和微量矿物质锌，镁和铁是最普遍的不足之处。种族观察到抗氧化剂和甲基供体的摄入量不同，黑人和西班牙裔的摄入量始终低于同龄人（p ＜0.01）。较高的压力与抗氧化剂和甲基供体不足有关，尤其是在黑人[抗氧化剂（aOR：2.09，95％CI 1.15-3.80）和甲基供体（aOR：2.22，95％CI 1.16-4.25）不足之间）。结论：观察到的饮食中抗氧化剂/甲基供体的种族差异可能部分解释了对环境毒物（例如交通污染）的脆弱性以及随之而来的健康差异的差异。下一步将包括评估饮食不足对不同种族人群中与交通污染相关的胎儿编程作用的影响。

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