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首页> 外文会议>Annual conference of the International Society of Exposure Science >Early life exposure for endocrine disrupting chemicals and the risk for asthma and allergy in children
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Early life exposure for endocrine disrupting chemicals and the risk for asthma and allergy in children

机译：早期接触内分泌破坏性化学物质以及儿童哮喘和过敏的风险

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We are focusing on environmental risk factors for asthma and allergy in children in two studies; the dampness in buildings and health (DBH) and the Swedish environmental, longitudinal, mother and child, asthma and allergy (SELMA) study. In the DBH-study we are following more than 10,000 children from early life up in school age. A major focus has been on suspected endocrine disrupting chemicals (EDCs) such as phthalates that are used in building materials (e.g., PVC) and consumer products. We have shown that PVC flooring in the homes bedrooms is related to indoor dust concentration of phthalates and to uptake of phthalates in infant children. We have further reported that PVC flooring in the home in early life is associated to allergic diseases in both cross sectional and longitudinal (incidence) data. Finally, we have reported associations between the bedroom dust concentration of phthalates and allergic outcomes in children. With these findings as a ground we are now focusing on asthma and allergy in the SELMA study. The SELMA study provides an extensive dataset including biological samples stored in a biobank (urine/serum from 1st trimester, cord blood, urine form the child at 2 and 12 months of age), environmental samples stored frozen (air and dust from the home the during pregnancy and infancy period), questionnaire data from eight times (2 times during pregnancy and at 2, 6,12,18, 48 and 72 months of age of the child), and access to data from the routinely made health examinations of the children at the County Council of Varmland. Overall aim is to examine the importance of prenatal exposure for EDCs for chronic diseases/disorder in offspring children including immunological outcomes of asthma and allergy. We now have data on 1st trimester exposure for 10 phthalates, 2 phenols and 8 perfluorinated compounds and we will conduct a health examination of 2,000 children at the age of 6 years including sampling for genetic/epigenetic analyses.
机译：在两项研究中，我们关注儿童哮喘和过敏的环境危险因素;建筑物和健康的湿度（DBH）以及瑞典的环境，纵向，母婴，哮喘和过敏（SELMA）研究。在DBH研究中，我们跟踪了10,000多名学龄前的儿童。主要关注于可疑的内分泌干扰化学物质（EDC），例如用于建筑材料（例如PVC）和消费品的邻苯二甲酸盐。我们已经表明，家庭卧室的PVC地板与室内邻苯二甲酸盐的粉尘浓度和婴儿中邻苯二甲酸盐的摄入量有关。我们还报告说，早期的家庭中PVC地板的横截面和纵向（发病率）数据均与过敏性疾病有关。最后，我们报告了卧室邻苯二甲酸盐粉尘浓度与儿童过敏结局之间的关联。基于这些发现，我们现在在SELMA研究中将重点放在哮喘和过敏上。 SELMA研究提供了一个广泛的数据集，包括生物样本库中存储的生物样本（早孕期的尿液/血清，脐带血，2和12个月大的孩子的尿液），冷冻保存的环境样本（家中的空气和灰尘）在怀孕和婴儿期），八次问卷调查（怀孕期间两次，以及在孩子的2、6、12、18、48和72个月时两次），并从例行的健康检查中获得数据Varmland县议会的孩子们。总体目标是要检查出生后暴露于EDC对后代慢性疾病/疾病的重要性，包括哮喘和过敏的免疫学结果。现在，我们有10个邻苯二甲酸盐，2个酚和8个全氟化合物在孕早期的数据，我们将对2,000名6岁的儿童进行健康检查，包括进行基因/表观遗传学分析的样本。

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