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Systemic Study on Association between Dioxin and liver Cancer

机译：二恶英与肝癌关系的系统研究

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Background. Animal study has shown that dioxin-sensitive rats exhibit significant transcriptional heterogeneity in hepatic responses to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD). There are many studies on the association between the dioxin exposures and human cancers, but with conflict results including studies for liver cancer as well. A meta-analysis may evaluate the association. Aims. For this systemic review, we search for studies published in the recent 2 decades that reported the association between dioxin exposures and liver cancer risks. Methods. We searched Pubmed and Medline for reports published in journals in English using key words limited to 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD, human exposure, liver cancer, liver cancer cell proliferation and hepatic neoplastic development. We identified 5 studies with relative risks (RRs) of liver cancer or liver cancer mortality measured by exposure levels assessed based on place of residence for general population and farmers, and for males and females. Results. Compared with residential areas of the lowest exposure levels, none of the reported 21 RRs of liver cancer or liver cancer mortality for residents with higher exposures were significant, ranging from 0.0 (95% CI 0.0-3.9) to 1.3 (95% CI 0.3-3.8). Conclusions. Residents living in the high exposure areas are not at a higher risk of liver cancer or mortality from liver cancer. The pathway of human exposure to dioxin based on the place of residence is not clear. The exposure levels are probable not high enough to assess the causal relationship.
机译：背景。动物研究表明，对二恶英敏感的大鼠在肝脏对2,3,7,8-四氯二苯并-p-二恶英（TCDD）的反应中表现出明显的转录异质性。关于二恶英暴露与人类癌症之间关系的研究很多，但结果矛盾，包括对肝癌的研究。荟萃分析可以评估这种关联。目的对于本系统综述，我们寻找最近2年间发表的研究，这些研究报告了二恶英暴露与肝癌风险之间的关联。方法。我们在Pubmed和Medline中搜索了英文期刊上发表的报告，使用的关键词仅限于2,3,7,8-四氯二苯并-p-二恶英，TCDD，人体暴露，肝癌，肝癌细胞增殖和肝肿瘤的发展。我们确定了5项肝癌或肝癌死亡率的相对风险（RR），这些风险是通过基于普通人群和农民以及男性和女性居住地的暴露水平评估的暴露水平来衡量的。结果。与最低暴露水平的居民区相比，已报道的较高暴露水平的居民的21项肝癌或肝癌死亡率的RR均无统计学意义，范围从0.0（95％CI 0.0-3.9）到1.3（95％CI 0.3- 3.8）。结论生活在高暴露地区的居民患肝癌或因肝癌致死的风险并不高。人们根据居住地暴露于二恶英的途径尚不清楚。暴露水平可能不足以评估因果关系。

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