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A SLIC response to lead and health

机译：SLIC对铅与健康的回应

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Background The World Health Organization estimates that lead is responsible for 143,000 deaths per year and 0.6% of the global burden of disease. However, prevalence rates for lead poisoning and the severity of outcomes vary greatly from country to country. In the UK, public health interventions have succeeded in removing most sources of lead from the human environment, however a small proportion of children continue to be exposed to harmful levels of lead, usually in the home. There are no reliable data on the incidence of lead toxicity in children in the UK or Republic of Ireland (ROI). Aim Surveillance of raised Blood Lead levels In Children (SLIC) is a Health Protection Agency (HPA) study aiming to provide an estimate of the incidence of blood lead concentrations ≥10μg/dl in the UK and ROI. Methods Cases were recruited over 24 months, using the methodology developed and managed by the British Paediatric Surveillance Unit for reporting of selected paediatric conditions by clinicians. To increase data capture, toxicologists and Supra-Regional Assay Service Trace Elements laboratories are also involved in case reporting. We will estimate incidence and use this information to identify the location of likely hotspots for exposure to lead in the UK and ROI. Results A successful system was established for reporting of cases by clinicians and laboratories across the countries involved. Cases were recruited from June 2010 to May 2012, and follow up is ongoing to link clinical and laboratory reports and remove double counting. Conclusions Childhood lead poisoning is preventable. The SLIC project will provide important information on both the clinical and public health management of lead poisoning cases in the UK and ROI. In all cases of lead toxicity globally, prevention should be a primary public health objective. Initiatives seeking greater national and international collaboration will help us to better understand and address the health challenges that lead presents.
机译：背景技术世界卫生组织估计，铅负责每年143,000人死亡，占全球疾病负担的0.6％。然而，铅中毒的患病率和结果的严重程度从国家到国家的国家变化很大。在英国，公共卫生干预措施取得了成功地消除了人类环境的大多数领先来源，但是一小部分儿童继续暴露于有害的铅，通常在家里。关于英国或爱尔兰共和国（ROI）的儿童潜在毒性发病率没有可靠的数据。 AIM监测儿童（SLIC）的血铅铅水平是一种健康保护局（HPA）的研究，旨在提供英国和投资回报率≥10μg/ dl的血铅浓度≥10μg/ dl的估计。方法使用英国儿科监测单元开发和管理的方法招聘方法，以报告临床医生的选定儿科病症。为了增加数据捕获，毒理学家和关于案例报告的毒理学家和Supra-区域测定服务痕量元素实验室也参与其中。我们将估算发病率并使用此信息来确定可能在英国和投资回报率下曝光的热点的位置。结果成立了成功的制度，以报告临床医生和实验室涉及的国家。案件于2010年6月至2012年5月招聘，随访正在进行链接临床和实验室报告，并删除双重计数。结论儿童铅中毒是可预防的。 SLIC项目将提供关于英国和ROI铅中毒案件临床和公共卫生管理的重要信息。在全球所有铅毒性的情况下，预防应该是主要的公共卫生目标。寻求更大国家和国际合作的举措将有助于我们更好地了解并解决铅礼物的健康挑战。

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