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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI
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Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI

机译：使用MRI改变载脂蛋白E4（ApoE4）携带者的小世界解剖网络

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Apolipoprotein E (ApoE) gene and primarily its allele e4 have been identified as a risk factor for Alzheimer's disease (AD). The prevalence of the gene in 25–30% in the population makes it essential to estimate its role in neuroregulation and its impact on distributed brain networks. In this study, we provide computational neuroanatomy based interpretation of large-scale and small-world cortical networks in cognitive normal (CN) subjects with differing Apolipoprotein-E4 (ApoE4) gene expression. We estimated large-scale anatomical networks from cortical thickness measurements derived from magnetic resonance imaging in 147 CN subjects explored in relation to ApoE4 genotype (e4+ carriers (n=41) versus e4- non-carriers (n=106)). Brain networks were constructed by thresholding cortical thickness correlation matrices of 68 bilateral regions of the brain analyzed using well-established graph theoretical approaches. Compared to ApoE4 non-carriers, carriers showed increased interregional correlation coefficients in regions like precentral, superior frontal and inferior temporal regions. Interestingly most of the altered connections were intra-hemispheric limited primarily to the right hemisphere. Furthermore, ApoE4 carriers demonstrated abnormal small-world architecture in the cortical networks with increased clustering coefficient and path lengths as compared to non-carrier, suggesting a less optimal topological organization. Additionally non-carriers demonstrated higher betweenness in regions such as middle temporal, para-hippocampal gyrus, posterior cingulate and insula of the default mode network (DMN), also seen in subjects with AD and mild cognitive impairment (MCI). The results suggest that the complex morphological cortical connectivity patterns are altered in ApoE4 carriers as compared to non-carriers, providing evidence for disruption of integrity in large-scale anatomical brain networks.
机译：载脂蛋白E（ApoE）基因及其主要等位基因e4已被确定为阿尔茨海默氏病（AD）的危险因素。该基因在人群中的流行率为25-30％，因此必须估计该基因在神经调节中的作用及其对分布式脑网络的影响。在这项研究中，我们提供了基于计算神经解剖学的大型和小世界皮层网络的解释，这些网络具有不同的载脂蛋白E4（ApoE4）基因表达。我们根据与ApoE4基因型（e4 +携带者（n = 41）对e4-非携带者（n = 106））有关的ApoE4基因型在147个CN受试者中通过磁共振成像得出的皮层厚度测量值估计了大规模解剖网络。使用成熟的图论方法，通过分析大脑的68个双侧区域的皮质厚度相关矩阵的阈值来构建大脑网络。与ApoE4非携带者相比，携带者在中枢，上额额叶和颞下区域等区域显示出更高的区域间相关系数。有趣的是，大多数改变的连接是半球内的，主要限于右半球。此外，与非载体相比，ApoE4载体在皮质网络中表现出异常的小世界结构，其聚类系数和路径长度增加，表明拓扑结构的最佳化。另外，非携带者在中颞，海马旁回，后扣带和默认模式网络（DMN）的区域表现出更高的中介性，在患有AD和轻度认知障碍（MCI）的受试者中也可见到。结果表明，与非载体相比，ApoE4载体中复杂的形态学皮质连通性模式发生了变化，为大规模解剖脑网络完整性的破坏提供了证据。

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