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Heart rate variability in children with cyanotic and acyanotic congenital heart disease: analysis by spectral and non linear indices

机译:Cyanistic和患有患有紫玉米心脏病的儿童心率变异性:光谱和非线性指标分析

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Congenital heart defects affect the efficiency and functionality of the heart, and autonomic control of heart rate and of circulation can display a pathologic behavior in order to compensate for the hemodynamic alterations due to disease. While previous works have investigated heart rate variability (HRV) in specific pathologies, e.g. tetralogy of Fallot, the goal of this study was to assess HRV in children with a congenital heart malformation taking into account the effects of cyanotic and acyanotic defects, and comparing pathologic children with age matched controls. HRV, approximate entropy (ApEn) and sample entropy (SampEn) were calculated to discuss the dynamics and complexity of heart rhythms, and to evaluate the potential impairment of control mechanisms. Analyses showed that low frequency (LF) power and total power of HRV were significantly higher in children with a condition than in healthy controls, independently of cyanosis. Non linear indices were also significantly higher in pathologic subjects. Significant differences in LF, total power, ApEn and SampEn were found among cyanotic, acyanotic and healthy children. These results suggested that children with a congenital heart condition display more complex HRV and sympathetic overactivity, which may be aimed at compensating for hemodynamic alterations. Further studies should investigate whether corrective surgery and rehabilitation can improve HRV and restore its physiological features.
机译:先天性心脏缺陷影响心脏的效率和功能,并且心率和循环的自主控制可以显示出病理行为,以便补偿由于疾病引起的血液动力学改变。虽然以前的作品在特定病理学中调查了心率变异性(HRV),例如,本研究的目的的目的是评估具有先天性心脏畸形的儿童的HRV,同时考虑了紫绀和杀虫病缺陷的影响,并将病理儿童与年龄匹配的对照进行比较。 HRV,近似熵(APEN)和样本熵(XEN)计算,以讨论心律的动态和复杂性,并评估控制机制的潜在损害。分析表明,患儿的低频(LF)功率和HRV的总功率明显高于健康对照,独立于紫绀。病理受试者的非线性指数也显着较高。在紫绀,杀菌和健康儿童中发现了LF,总功率,APEN和Sampen的显着差异。这些结果表明,具有先天性心脏条件的儿童更复杂的HRV和交感神经过效,这可能旨在补偿血液动力学改变。进一步的研究应调查矫正手术和康复是否可以改善HRV并恢复其生理特征。

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