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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Hemodynamics changes with acute carotid baroreceptor field stimulation are age-dependent in normotensive rats*
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Hemodynamics changes with acute carotid baroreceptor field stimulation are age-dependent in normotensive rats*

机译：血流动力学随着急性颈动脉的变化而变化，急性颈动脉探测器场刺激是依赖于正常抗衰老的大鼠*

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Carotid baroreceptor stimulation can treat resistant hypertension with possible effects on the vasculature beyond the decrease in arterial pressure. This study aims to characterize age-dependency of vascular hemodynamics changes with unilateral field stimulation of carotid baroreceptors in normotensive rats to infer underlying hemodynamic mechanisms. Anesthetized Wistar-Kyoto rats divided into two groups (young: n=10, 13-33 weeks; old: n=6, 52-58 weeks) were instrumented to measure heart rate (HR) and mean arterial pressure (MAP), and flow in the abdominal aorta and renal artery. Measures of aortic and renal artery stiffness and resistance were calculated. Baroreceptor stimulation caused a consistent reduction in MAP, HR, pulse pressure and aortic pulse wave velocity. In young rats reduced MAP (77±10 to 64±13 mmHg, p<;0.001) was concomitant with reduced mean aortic (40±15 to 32±11 ml/min, p<;0.05) and renal flow (3.0±1.6 2.2±1.1 ml/min, p<;0.001). However, in old rats reduced MAP (76±14 to 64±10 mmHg, p<;0.05) occurred with a reduced aortic resistance (1.8±0.9 to 1.6±0.9 mmHg.min/ml, p<;0.05), renal artery resistance (17.4±2.4 to 16.5±2.3 mmHg.min/ml, p<;0.05) and mean renal flow (4.5±1.2 to 4.0±1.1 ml/min, p<;0.05). This was consistent with reduced characteristic impedance in older rats in both the aorta (0.17±0.08 to 0.13±0.08 mmHg.min/ml, p<;0.05) and renal artery (4.97±1.16 to 3.97±1.08 mmHg.min/ml, p<;0.05). Stimulation caused a leftward shift in renal impedance phase frequency spectrum in both age groups indicating changes in wave reflection from the renal bed. Findings show that the reduction in MAP due to carotid barostimulation is associated with different hemodynamic mechanisms that depend on age.
机译：颈动脉的丧失运动刺激可以治疗抗性高血压，可能对脉管系统的影响超出了动脉压的降低。本研究旨在表征血管血流动力学的年龄依赖性随着规范性大鼠中颈动脉丧失患者的单侧场刺激，以推断出潜在的血流动力学机制。麻醉的Wistar-kyoto大鼠分为两组（杨：n = 10,13-33周;旧：n = 6,52-58周）被称为测量心率（HR）和平均动脉压（MAP），以及流动在腹主动脉和肾动脉。计算了主动脉和肾动脉僵硬度和抗性的测量。呼吸器刺激导致MAP，HR，脉冲压力和主动脉脉搏波速度的一致减少。在幼鼠中，降低地图（77±10至64±13mmHg，P <; 0.001）伴随着平均主动脉（40±15至32±11ml / min，P <; 0.05）和肾流动（3.0±1.6 2.2±1.1 ml / min，p <; 0.001）。然而，在旧的大鼠中，降低映射（76±14至64±10 mmHg，P <; 0.05），具有降低的主动脉性（1.8±0.9至1.6±0.9 mmHg.min / ml，p <0.05），肾动脉电阻（17.4±2.4至16.5±2.3mmHg.min / ml，p <0.05）和平均肾流动（4.5±1.2至4.0±1.1ml / min，p <; 0.05）。这与Aorta（0.17±0.08至0.13±0.08 mmHg.min / ml，P <0.05）和肾动脉（4.97±1.16至3.97±1.08 mmhg.min / ml，这是一致的特性阻抗（0.17±0.08至0.13±0.13±0.13.08mmHg.08 mmhg.min / ml， P <; 0.05）。刺激导致肾脏阻抗相频谱的向左移位在两个年龄组中，表明来自肾脏床的波反射变化。调查结果表明，由于颈动脉畸形而导致的地图减少与依赖年龄的不同血液动力学机制有关。

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