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首页> 外文期刊>American Journal of Physiology >Chronic isolation of carotid sinus baroreceptor region in conscious normotensive and hypertensive rats.
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Chronic isolation of carotid sinus baroreceptor region in conscious normotensive and hypertensive rats.

机译：慢性正常和高血压大鼠颈动脉窦压力感受器区域的慢性隔离。

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摘要

We have developed a chronic technique to isolate the carotid sinus baroreceptor region in the conscious rat model. Our technique, when used in conjunction with other methods, allows for the study of the control of arterial pressure, heart rate, and cardiac output by the carotid sinus baroreceptor reflex in conscious, unrestrained rats. The performance of our technique was evaluated in two strains: normotensive Sprague-Dawley (SD) rats and spontaneously hypertensive rats (SHR). Each rat was instrumented with an aortic flow probe and a catheter placed in the right femoral artery to monitor cardiac output and arterial pressure, respectively. The cervical sympathetic trunk and aortic depressor nerve were ligated and cut bilaterally, leaving vagus nerves intact. The right and left carotid sinuses were isolated using our new technique. We tested the open-loop function of the carotid sinus baroreceptor reflex system in the conscious rat after recovery from the isolation surgery. We found that changes in nonpulsatile carotid sinus pressure caused significant changes in arterial pressure, heart rate, and total peripheral resistance in both rat strains. However, the cardiac output responses differed dramatically between strains. Significant changes were seen in the cardiac output response of SHR, whereas no significant changes were observed in normotensive SD rats. We have found this technique to be a highly reliable tool for the study of the carotid sinus baroreceptor reflex system in the conscious rat.
机译：我们已经开发出一种慢性技术来分离清醒大鼠模型中的颈动脉窦压力感受器区域。当与其他方法结合使用时，我们的技术可以研究有意识的，不受约束的大鼠的颈动脉窦压力感受器反射对动脉压，心率和心输出量的控制。我们在两种品系中评估了我们的技术的性能：血压正常的Sprague-Dawley（SD）大鼠和自发性高血压大鼠（SHR）。每只大鼠均配备有放置在右股动脉中的主动脉流量探针和导管，以分别监测心输出量和动脉压。结扎颈交感神经干和主动脉压迫神经，双侧切开，保留迷走神经。使用我们的新技术分离出左右颈动脉窦。从隔离手术中恢复后，我们在有意识的大鼠中测试了颈窦窦压力感受器反射系统的开环功能。我们发现非脉动性颈动脉窦压力的变化引起了两种大鼠品系的动脉压，心率和总外周阻力的显着变化。但是，不同菌株之间的心输出量反应差异很大。在SHR的心输出量反应中观察到显着变化，而在血压正常的SD大鼠中未观察到显着变化。我们发现该技术是用于研究清醒大鼠颈动脉窦压力感受器反射系统的高度可靠的工具。

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