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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Mathematical modeling of tumor response to radiation: radio-sensitivity correlation with BOLD, TOLD, ΔR1 and ΔR2* investigated in large Dunning R3327-AT1 rat prostate tumors
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Mathematical modeling of tumor response to radiation: radio-sensitivity correlation with BOLD, TOLD, ΔR1 and ΔR2* investigated in large Dunning R3327-AT1 rat prostate tumors

机译：肿瘤肿瘤反应的数学建模：大胆的无线电敏感性相关性，ΔR 1 *在大灾害R3327-AT1大鼠前列腺肿瘤中研究

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Tumor response to radiation therapy can vary highly across patients. Several factors, both tumor- and environment-specific, can influence the radio-sensitivity, one of the most well-known being hypoxia. In this work, we investigated possible correlations between the radio-sensitivity parameters determined by means of a simple mathematical model of tumor volume evolution, and the MRI-based indicators of oxygenation in Dunning R3327-AT1 rats. Prior to irradiation the rats were subjected to an oxygen-breathing challenge, which was evaluated by MRI. The tumors were administered a single irradiation dose (30 Gy), while breathing air or oxygen. Despite a poor fitting performance, the model was able to identify two different tumor volume regression patterns. Moreover, the radio-sensitivity of the oxygen-breathing group was found to correlate with the variation of the transverse relaxation rate ΔR* (-0.89). This suggests that MRI-based indices of tumor oxygenation may provide information about radio-sensitivity.
机译：对放射治疗的肿瘤反应可以在患者身上产生高度。肿瘤和环境特异性的几个因素可以影响无线电敏感性，最着名的缺氧之一。在这项工作中，我们研究了通过肿瘤体积演化的简单数学模型确定的无线电敏感性参数之间的可能相关性，以及令人垂涎的R3327-AT1大鼠中的基于MRI的氧合指标。在照射之前，对大鼠进行氧气呼吸攻击，其被MRI评估。肿瘤施用单一照射剂量（30Gy），同时呼吸空气或氧气。尽管拟合性能不佳，但该模型能够识别两种不同的肿瘤体积回归模式。此外，氧呼吸群的电波灵敏度发现关联与横向弛豫速率ΔR*（-0.89）的变化。这表明肿瘤氧合的基于MRI的索引可以提供关于无线电灵敏度信息。

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