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Postprandial blood glucose control in type 1 diabetes for carbohydrates with varying glycemic index foods

机译:1型糖尿病患者的餐后血糖对照,碳水化合物不同血糖指数食物

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Treatment of type 1 diabetes consists of maintaining postprandial normoglycemia using the correct prandial insulin dose according to food intake. Nonetheless, it is hardly achieved in practice, which results in several diabetes-related complications. In this study we present a feedforward plus feedback blood glucose control system that considers the glycemic index of foods. It consists of a preprandial insulin bolus whose optimal bolus dose and timing are stated as a minimization problem, which is followed by a postprandial closed-loop control based on model predictive control. Simulation results show that, for a representative carbohydrate intake of 50 g, the present control system is able to maintain postprandial glycemia below 140 mg/dL while preventing postprandial hypoglycemia as well.
机译:1型糖尿病的治疗包括使用根据食物摄入的正确折叠胰岛素剂量保持餐后常规血糖。 尽管如此,实际上几乎没有实现,这导致几种糖尿病相关的并发症。 在这项研究中,我们提出了一种馈送加上反馈血糖控制系统,其考虑了食物的血糖指数。 它由预胰岛素推注组成,其最佳推注剂量和定时被称为最小化问题,其次是基于模型预测控制的餐后闭环控制。 仿真结果表明,对于50g的代表性碳水化合物摄入量,目前的控制系统能够在低于140mg / dl以下的后糖血症,同时预防后催化剂也是如此。

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