Regarding 2D applications of the BG-NPs, bioactive nanocomposites were obtained by casting chitosan solutions containing the nanoparticles. BG-NPs were also doped with magnesium in order to enhance their biological influence. Results showed a positive effect on the osteoblastic response. In an extension to the previous successful results, mCP technique was used to control spatially the mineralization of chitosan membranes. A valuable and polyvalent platform was created to push even further the study of mineralization and cellular interactions. At the 3D, a bottom-up approach to produce hierarchically organized BG-NPs based structures was used successfully. The results showed that BG-NPs are capable of self-assemble into organized multilevel structures. Therefore, self-assembly proved to be a powerful tool in mimicking mineralized structures. The described research work is based on simple techniques highly competitive against other existing technologies for bone's structure mimicking. Control over the BG-NPs distribution and was achieved at 2D. However, it would be interesting to develop modes of also extending the spatial control of mineralization to 3D structures, namely in hydrogels and scaffolds, in order to target the particles potential in a wider range of BTE applications.
展开▼
