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首页> 外文会议>International Conference on Biomedical Engineering >In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice
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In-vivo evaluation of ultrasound transducers for noninvasive transdermal delivery of insulin using temporarily hyperglycemic rabbits and mice

机译：临时高血糖兔和小鼠的非侵入性透皮递送的超声换能器的体内评价

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A noninvasive transdermal delivery of insulin, using piston-shaped PZT ultrasound transducers, was suggested to reduce regular pain and suffering of type 1 diabetic patients. This alternative technique is intended to replace the long-term dependence on multiple subcutaneous insulin injections. Ten rabbits and ten mice were divided equally into four groups (two control groups and two exposure groups). The animals were anesthetized using a combination of Ketamine hydrochloride and Xylazine to produce temporarily diabetic animal models during the periods of the experiments. Animals in control groups did not receive ultrasound while animals in exposure groups received ultrasound mediated delivery of insulin for 5 and 10 minutes for mice and rabbits, respectively, during the continuous driving of the transducers. Sweep driving frequency signals were assigned to each exposure group with frequency range from 100 to 200 kHz. The signals were amplified to drive 30.0 mm diameter piston-shaped PZT transducers attached to the shaved skin of each exposed anesthetized animal. Custom made housing was used to create a reservoir to trap insulin between the face of the transducer and the exposed shaved abdomen areas of the animals during the delivery period. Blood glucose levels were measured depending on blood samples from the veins of the tails of the mice and the veins of the ears of the rabbits. These measurements were achieved using blood glucose meter every ten minutes for an hour starting from the delivery period. Over the recording period of 60 minutes, reduction of blood glucose levels compared to control groups were 67% and 50% for rabbits and mice, respectively. Ultrasound piston PZT transducers in the mid range frequency (100 to 200 kHz) were found feasible in transdermal insulin delivery in vivo using temporarily hyperglycemic rabbits and mice models.
机译：使用活塞形PZT超声换能器的胰岛素的非侵袭性透皮递送，以减少1型糖尿病患者的常规疼痛和痛苦。这种替代技术旨在取代对多个皮下胰岛素注射的长期依赖性。将十只兔子和十只小鼠同样分为四组（两组对照组和两组）。使用盐酸氯胺酮和木嗪的组合麻醉动物，以在实验期间产生暂时的糖尿病动物模型。对照组的动物没有接受超声，而暴露基团中的动物分别在换能器的连续驱动过程中分别接受过量介导的胰岛素5和10分钟的胰岛素。扫描驱动频率信号被分配给每个曝光组，频率范围为100至200 kHz。扩增信号以驱动30.0mm直径的活塞形PZT换能器，其附着在每个暴露的麻醉动物的剃剃头上。定制外壳用于创建储存器，以在交付期间捕获换能器的面部与动物的暴露剃毛腹部区域之间的胰岛素。根据小鼠尾部的血管和兔耳的静脉的血样测量血糖水平。使用血糖计每十分钟开始从交货期开始一小时实现这些测量。在60分钟的记录期间，与对照组相比减少血糖水平分别为兔和小鼠的67％和50％。在使用临时高血糖兔和小鼠模型中，在体内透皮胰岛素递送中发现了中范围频率（100至200kHz）中的超声波活塞PZT换能器。

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